References Vector Promoter NTFs Delivery route Effects Animal Staecker et al. [28] HSV-1 HSV-1 IE 4/5 promoter BDNF Scala tympani SGN survival Ototoxically deafened mice Yagi et al. [29] Ad5-CMV…
Fig. 26.1 Schematic representation of the developing SGNs in mice, modified Coate and Kelley [3]. (a) Neuroblasts delaminate from the otocyst and form the CVG. (b) The last wave of…
Fig. 24.1 Challenges to be overcome in cell therapy for hair cell regeneration. In left hand, requirements for preparation and transplantation of stem/progenitor cells are listed. In the middle, survival,…
Gene Vector Recipient animal References Catalase AdV Guinea pig [32] Atoh1 AdV Guinea pig [4, 35] Atoh1 AdV Mouse [36, 37] GDNF/TGFbeta AdV Guinea pig [31] NOX3 (siRNA) Rat [34]…
Fig. 22.1 Overview of dedifferentiation-mediated hair cell regeneration. Dedifferentiation-mediated hair cell regeneration involves a dedifferentiation step (dashed arrow) and a subsequent redifferentiation step (arrow). iPS transcription factors (TFs) and epigenetic…
Fig. 20.1 Summary of critical events and therapeutic drugs after hair cell damage in the apoptotic process. Just after hair cell damage, ROS and JNK are activated. Several hours later,…
Fig. 16.1 Schematic representation of the targets and methods for the regenerative medicine in cochlear implantation. The electrode of cochlear implant was placed in the scala tympani. Neurotrophic factors, stem…
Fig. 14.1 Tonotopic organization in the cochlea and the cochlear nucleus. Black, dark gray, and light gray lines represent high, middle, and low frequencies, respectively. In the cochlea, a simple…
Fig. 7.1 Hair cell synapses in the cochlea [2] Synaptic ribbons are electron-dense structures that are located at the base of hair cells and play a role as a pool…
Fig. 5.1 Cochlear lateral wall and potassium ion recycling. The ionic composition with high potassium concentration and endocochlear potential are maintained by ion transport through the cochlear lateral wall. Potassium…
