Fig. 8.1 Schematic representation of the relationships between afferent and efferent auditory nerve fibers with two types of sensory hair cells. Spiral ganglion neurons (SGNs) are clustered in Rosenthal’s canal (RC)…
Fig. 3.1 Overview of neurotrophin expression and effects of neurotrophin loss. Two neurotrophins, Bdnf and Ntf3, are expressed in the developing organ of Corti. Bdnf is nearly exclusively found in hair…
Fig. 4.1 The peripheral innervation patterns and classical morphologies of spiral ganglion neurons are illustrative of their respective functional specializations. a Image of the vestibular and auditory bony structures within the…
Fig. 6.1 Schematic drawing of spiral ganglion neurons and their central and peripheral terminations. The type I neuron (black) innervates a single IHC and projects in a topographic fashion into the…
Fig. 5.1 Radial section schematic of spiral ganglion neurons in the cochlea. a The spiral ganglion is on left, showing several somas of type I spiral ganglion neurons (SGNs) all connected…
Fig. 1.1 Auditory neurons connect mechanosensory hair cells in the organ of Corti to cochlear nuclei neurons in the brain stem. a Cross section through the cochlea and brain stem of…
Fig. 2.1 Morphogenesis of the spiral ganglion. The spiral ganglion develops from a proneurosensory region (dark gray) in the anteroventral quadrant of the otic cup, beginning around E9 in mouse. Over…
Cell type/preparation Auditory neural markers detected Electrical activity detected ✓ or ✕ New synapses detected ✓ or ✕ References Embryonic stem cells HESC Pax2, Brn3a, GATA3, βIII tubulin, peripherin ✕…
Fig. 7.1 Organotypic cochlear culture. a, b Fixed cochlear wholemounts viewed at low (a, scale bar = 100 µm) and high (b, scale bar = 20 µm) magnification. Spiral ganglion (SG) and organ of Corti (OC) are…
