The Effects of Lutein in Preventing Cataract Progression
Substance Amount Lutein 6.0 mg Vitamin C 300.0 mg Vitamin E 60.0 mg Vitamin B2 3.0 mg β-carotene 1,200.0 μg Niacin 12.0 mg Zinc 9.0 mg Selenium 45.0 μg Copper…
Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells
Fig. 8.1 Carcinine is efficiently transported to the retina following topical administration. Mice received carcinine dissolved in eye drop formulation (glycerol 1 %, carboxymethylcellulose 0.3 %, benzyl alcohol 0.3 %,…
Excitatory Amino Acid Transporters, Xc− Antiporter, γ-Glutamyl Transpeptidase, Glutamine Synthetase, and Glutathione in Human Corneal Epithelial Cells
Fig. 4.1 Uptake of radiolabeled (a) l-Glu, (b) d-Asp, and (c) l-Cys by Na+-dependent and Na+-independent transport systems in HCEC. Each point represents the mean CPM/culture and SEM of three…
Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts
Fig. 18.1 Slit lamp photo of (a) age-related cortical cataract; (b) age-related nuclear cataract Cortical Cataracts Cortical spokes (wedge shaped opacities) form in the periphery of the lens with the…
Etiology and Prevention of Cataract
Unmodifiable risk factors Modifiable risk factors 1. Race 1. Oxidative stress-related factors 2. Sex 2. Maternal malnutrition 3. Age 3. Medication and physical exercise 4. Genetics 4. Smoking and alcoholism…
p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation
12. Kilpivaara O, Aaltonen LA. Diagnostic cancer genome sequencing and the contribution of germline variants. Science. 2013;339(6127):1559–62.PubMed 13. Purvis JE, Lahav G. Encoding and decoding cellular information through signaling dynamics….
Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis
18. Sanwal M, Muel AS, Chaudun E, Courtois Y, Counis MF. Chromatin condensation and terminal differentiation process in embryonic chicken lens in vivo and in vitro. Exp Cell Res. 1986;167:429–39.PubMedCrossRef…
Oxidative Stress in Lens
Fig. 11.1 Summary of oxidative stress defense system in eye lens. Multiple exogenous (ultraviolet light, drugs, metals, and smoke) and endogenous (peroxisomes, lipooxygenases, immune activity and altered mitochondrial respiration) sources…
Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis
© Springer Science+Business Media New York 2015Mark A. Babizhayev, David Wan-Cheng Li, Anne Kasus-Jacobi, Lepša Žorić and Jorge L. Alió (eds.)Studies on the Cornea and LensOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-1-4939-1935-2_9 9. Basic Review of…
Corneal Stem Cells: A Source of Cell Renewal with Therapeutic Potential
Fig. 6.1 Expression of p63 in the basal epithelium of the human limbus. Representative confocal microscope images of human corneas immunolabeled with antibody specific to the putative stem cell marker…
