Biomarkers to Predict Glaucoma Surgical Success
Aqueous humor Trabecular meshwork Optic nerve Systemic (serum/plasma) ECM elements CD44 ↓ [13] Cochlin ↑ [14] Chondroitin sulfate ↑ [15] Collagen type IV nc [16] Elastin ↑ [17] ↑…
Intraoperative Assessment of the Conventional Collector Outflow System as Therapeutic Target
Fig. 2.1 Aqueous outflow. Aqueous exits the eye through either trabecular or uveoscleral channels. Trabecular outflow, seen in red, is also termed pressure-dependent outflow and handles most of the flow…
SOLX Suprachoroidal Shunt
Fig. 23.1 Current model of SOLX Shunt, GMS Plus, and the prior model GMS The initial studies were done with the earlier model, Gold Micro Shunt, GMS, which was a…
Ahmed Glaucoma Valve Model M4
Fig. 20.1 Ahmed Glaucoma Valve M4 (porous plate). The device has a porous polyethylene shell, which allows soft tissue growth into pores and integration with surrounding tissue (Photograph courtesy New…
Laser Therapies: Cyclodestructive Procedures
Type Power/energy No. of shots Extent of area treated (degree) Avoid 3 and 9 o’clock position Noncontact TCP (Nd:YAG) 7–8 W for 0.02 s 24–32 (8 per quadrant) 270–360 Yes…
Ciliary Body as a Therapeutic Target
Fig. 4.1 This is an image of the OcuLight SLx, the most commonly used ophthalmic diode laser in the United States (Image courtesy of Iridex, Mountain View, CA) Fig. 4.2…
Suprachoroidal Space as a Therapeutic Target
Generic name Brand name in the USA Manufacturer Unoprostone Rescula CIBA Vision Ophthalmics, Bulach, Switzerland (also generically manufactured by other companies) Latanoprost Xalatan Pfizer Inc., New York, NY (also generically…
Clinical Trials for IOP-Lowering Devices to Support an FDA Premarket Submission
John R. Samples and Iqbal Ike K. Ahmed (eds.)Surgical Innovations in Glaucoma10.1007/978-1-4614-8348-9_5 © Springer Science+Business Media New York 2014 5. Clinical Trials for IOP-Lowering Devices to Support an FDA Premarket Submission Judy F. Gordon1 and Robert L. Kramm2 (1) ClinReg Consulting Services,…
Considerations in Patenting New Surgical Devices for Glaucoma: The Changing Patent Law Landscape
and Gabrielle LaHatte2 (1) Formerly an Intellectual Property Litigation Associate with Klarquist Sparkman, LLP, Portland, OR, USA (2) Formerly a Staff Attorney with Tarolli, Sundheim, Covell & Tummino, LLP, Cleveland, OH,…
Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System
(14.1) (14.2) (14.3) (14.4) (14.5) (14.6) (14.7) (14.8)Type II mechanism (14.9) (14.10) (14.11)In these mechanistic formulations, S, 1S, and 3S represent the sensitizer (S) in the ground state and in…
