Antimitotic and Immunosuppressive Chemotherapy Brian K. Do Alan H. Friedman Joel S. Mindel Few ophthalmologists are sufficiently familiar with the actions, toxicities, and side effects of antimitotic and immunosuppressive agents…
The Pharmacology of Prostaglandin Analogues Deepta Ghate MD Carl B. Camras MD Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha NE Supported in part by an…
Glucocorticoids Joel S. Mindel Hydrocortisone (cortisol) is the major naturally occurring glucocorticoid in humans. The blood level of hydrocortisone is determined by the rate of pituitary adrenocorticotrophic hormone (ACTH) secretion,…
Bioavailability Hari Krishna Ananthula Ravi D. Vaishya Megha Barot Ashim K. Mitra Bioavailability refers in general to the percentage of a drug that absorbs and reaches the potential site of…
Alpha-Adrenergic Drugs Joel S. Mindel CATECHOLAMINE-CONTAINING NEURONS OF THE EYE The eye is innervated by catecholamine-containing axons originating from the superior cervical ganglion, a sympathetic nervous system structure. These postganglionic…
Hyperosmotic Agents Eunice Lee Janet B. Serle Donna J. Gagliuso John Danias Systemically administered hyperosmotic agents have been used almost exclusively in the management of acute elevations of intraocular pressure…
Pharmacokinetics Joel S. Mindel DEFINITION Pharmacokinetics refers to how the patient’s tissues affect the therapeutic response. Factors such as drug penetration, drug metabolism, and drug excretion are considered. TOPICAL OCULAR…
Methods for Assessing the Effects of Pharmacologic Agents on Aqueous Humor Dynamics Rachel Peck Mieko Hayashi Michael E. Yablonski Joel S. Mindel Douglas J. Rhee BASIC PRINCIPLES The steady-state intraocular…
Compliance Jaqueline Lustgarten Introduction Patient adherence to a prescribed course of treatment is recognized as a critical component of effective therapy. Failure to comply with physicians’ orders, be they pharmaceutical…
The Use of Fluorescein Angiography in Acquired Macular Diseases Antonio P. Ciardella Stephen R. Kaufman Lawrence A. Yannuzzi Fluorescein angiography (FA) has been widely used clinically for more than 3…
