Figure 13.1 Spectral-domain OCT image demonstrating location of retinal layers in a healthy subject. Note black arrows denoting nerve fiber layer, inner plexiform layer, outer plexiform layer, external limiting membrane,…
Figure 7.1 Representative images of polypoidal choroidal vasculopathy (PCV). Pigment epithelial detachment (A) and subretinal hemorrhage (B) are common manifestations. C. Subretinal lipid is often observed. D. In some patients,…
Figure 5.1 Histopathological changes in the two main forms of AMD. This diagram is showing the structural and functional changes of a normal RPE cell when developing dry or wet…
Figure 16.1 Pegaptanib structure and target binding. A. Sequence and predicted secondary structure of pegaptanib. 2′-O-methylated purines are shown in red, 2′-fluorine-modified pyrimidines are shown in blue, and unmodified ribonucleotides…
At present, there are two general approaches by which therapeutic AAV-mediated gene transfer might be useful in the context of ocular disease. First, AAV-mediated gene therapy has the potential to…
