Not 48 Chromosomes, Only 46
Six decades ago, as the implications of the double helix were being pondered over, another basic discovery in medical genetics was quietly made. Since the 1920s, the standard chromosome count…
OPHTHALMOLOGY
Quantitative Trait Locus Analysis of SIX1-SIX6With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent
Purpose To perform a quantitative trait locus (QTL) analysis and evaluate whether a locus between SIX1 and SIX6 is associated with retinal nerve fiber layer (RNFL) thickness in individuals of…
Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study
Purpose To evaluate the relationship between rates of change on frequency doubling technology (FDT) perimetry and longitudinal changes in quality of life (QoL) of glaucoma patients. Design Prospective observational cohort…
Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort
Purpose To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. Design…
Macular Thickness Profiles of Intraretinal Layers in Myopia Evaluated by Ultrahigh-Resolution Optical Coherence Tomography
Purpose To investigate the thickness and variation profiles of 8 intraretinal layers in myopia. Design Prospective cross-sectional study. Methods Young subjects with spherical equivalents ranging from +0.50 to −10.25 diopters and good…
Choroidal Thickness Changes After Photodynamic Therapy and Recurrence of Chronic Central Serous Chorioretinopathy
Purpose To investigate long-term changes in subfoveal choroidal thickness (SCT) after photodynamic therapy (PDT) and their relationship with chronic central serous chorioretinopathy (CSC) recurrence. Design Retrospective, observational, comparative case series….
Characterization of Anatomic and Visual Function Outcomes in Patients With Full-Thickness Macular Hole in Ocriplasmin Phase 3 Trials
Purpose To characterize anatomic and visual outcomes in patients with full-thickness macular hole (FTMH) at baseline in ocriplasmin phase 3 clinical trials, focusing on the relationship between resolution of vitreomacular…
Incidence of Late-Stage Age-Related Macular Degeneration in American Whites: Systematic Review and Meta-analysis
Purpose To estimate incidence of age-related macular degeneration (AMD) by subtype in American whites aged ≥50 years. Design Systematic review and meta-analysis. Methods setting : Prospective cohort studies of AMD…
Correlation Between the Dynamic Postoperative Visual Outcome and the Restoration of Foveal Microstructures After Macular Hole Surgery
Purpose To analyze the long-term dynamic healing process of outer retinal changes for 1 year in patients who underwent a standard vitrectomy procedure for idiopathic macular hole (MH) repair. Design…
Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study
Purpose To evaluate how optical coherence tomography (OCT) angiography depicts clinical fundus findings in patients with diabetic retinopathy (DR). Design Prospective study evaluating imaging technology. Methods Forty-seven eyes of 25…
