Purpose To determine whether baseline drusen load, as measured using spectral-domain optical coherence tomography (SD OCT), is a useful predictor of development of advanced age-related macular degeneration (AMD). Design Retrospective cohort…
Purpose To evaluate serum and plasma vascular endothelial growth factor (VEGF) concentrations in neovascular age-related macular degeneration patients treated bimonthly with an intravitreal injection of aflibercept or ranibizumab. Design Prospective,…
Purpose To determine the effect of anti–vascular endothelial growth factor (VEGF) therapy on choroidal thickness in eyes with diabetic macular edema (DME). Design A retrospective, cohort analysis of 59 eyes…
Purpose To evaluate the safety, tolerability and bioactivity of ascending doses of MP0112, a designed ankyrin repeat protein (DARPin) that binds with high affinity to vascular endothelial growth factor-A (VEGF-A),…
Purpose To examine the association between best corrected visual acuity (BCVA) and subfoveal choroidal thickness. Design Population-based study. Methods The Beijing Eye Study 2011 included 3468 subjects with ages of…
Purpose To evaluate the concordance between pseudodrusen as manifested by subretinal drusenoid deposits and large choroidal blood vessels using stereological analysis of spectral-domain optical coherence tomography (SD OCT) images. Design…
Purpose To report the presenting features and clinical outcomes of a series of patients with noninfectious inflammation after intravitreal aflibercept injection. Design Noncomparative consecutive case series. Methods Medical records of…
Purpose To analyze choroidal sub-layers and vascular diameter in children, and to compare these choroidal features with those of adults. Design Retrospective observational study. Methods This study included 96 eyes…
The American Journal of Ophthalmology and Elsevier Inc. will jointly recognize Hans Grossniklaus, MD, MBA, at this year’s American Academy of Ophthalmology meeting in Chicago as the 71st Edward Jackson…
Purpose To critically assess the evidence base regarding outcomes following cataract surgery in uveitic cases. Design Systematic evidence-based review and meta-analysis. Methods A comprehensive search query was performed on MEDLINE,…
