6 Is It All VEGF? Other Angiogenic Factors

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 6 Is It All VEGF? Other Angiogenic Factors

FIGURE 6.1. The cyclooxygenase cascade. COX-1 and COX-2 catalyze the biosynthesis of prostanoids (prostaglandins and thromboxane) from membrane-derived arachidonic acid. The prostanoids then bind to their cognate GPCRs (G-protein coupled…

read more

1 Judah Folkman and Angiogenesis

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 1 Judah Folkman and Angiogenesis

However, when new blood vessels grew into the small tumors from the adjacent vascularized tissues of the eye, for example, retina or iris, the tumors grew quickly and overtook the…

read more

7

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 7

 ALTERNATIVES Medical Therapy Laser skin resurfacing reduces periorbital wrinkling but cannot address significant tissue redundancy or prolapse. Surgery Browplasty: Brow ptosis (age-related sagging of the brows) may contribute significantly to…

read more

3

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 3

Defects that affect the full stromal thickness and/or endothelial layer Late stage or acute keratoconus Accidental penetration of the anterior chamber during a lamellar procedure Emergency treatment of a perforated…

read more

5

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 5

Nonvalved Implants Molteno: The original drainage device, introduced in 1969. A third-generation model is available as a 175-mm2 or 230-mm2 single plate, made of rigid polypropylene (FIG. 5.1.1C). Older models…

read more

8

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 8

 INDICATIONS Intravitreal injections are an increasingly common therapeutic tool for addressing various retinal pathologies. Examples include: Antivascular endothelial growth factor (VEGF) agents for neovascular (“wet”) age-related macular degeneration (AMD) or…

read more

9

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 9

Canthotomy: After removing the hemostat, the crushed tissue is incised with laterally directed scissors (FIG. 9.1.2). Cantholysis: The inferior limb of the canthal tendon is placed on tension with toothed…

read more

4

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 4

 RELEVANT ANATOMY AND PATHOPHYSIOLOGY Lens Overview (FIG. 4.1.2) Origin: The lens is formed by embryologic invagination of the surface ectoderm. Attachments: The equator of the lens capsule is suspended by…

read more

6

Oct 8, 2016 by in OPHTHALMOLOGY Comments Off on 6

Muscle origins: All four rectus muscles originate from the Annulus of Zinn, a fibrous ring that encloses the optic canal and nerve at the orbital apex. The superior oblique and…

read more
Get Clinical Tree app for offline access