Human Papillomavirus and Head and Neck Cancer
Fig. 11.1 HPV carcinogenesis process 11.2 HPV+ HNSCC Burden Based on GLOBOCAN 2012 (Ferlay et al. 2015), head and neck cancer accounted for 4.8% of the 14.1 million new cancer…
OTOLARYNGOLOGY
Advocacy for Recurrent Respiratory Papillomatosis
Hoarseness 590 (80.2%) Breathing disorder 266 (36.1%) Swallowing disorder 130 (17.7%) Voice abnormality 541 (73.5%) Breathing abnormality during exercise 308 (41.8%) Breathing abnormality at rest 234 (31.8%) Active papilloma growth…
Fundamental Biology of Human Papillomaviruses
Viral gene Viral life cycle Transformation and oncogenesis Immune modulation E1 DNA helicase activity. Regulates viral gene transcription E2 Regulates early gene promoter Knockout due to integration of viral genome…
Malignant Transformation and Distal Airway Complications
Fig. 10.1 Tracheal papilloma at the distal tip of the indwelling tracheostomy tube One study noted that the right proximal bronchus was consistently more severely affected than the left (Blackledge…
Impact on Quality of Life
Fig. 6.1 Clinical score, modified from the Derkay-Coltrera RRP staging /severity score (Derkay et al. 1998) Unfortunately, there does not currently exist a validated, disease-specific tool for measuring HRQOL in…
The Cidofovir Controversy
Study Design Cohort Outcomes Bevacizumab Mohr et al. (2014) Case series Intravenous: 5–15 mg/kg per dose q 2–3 weeks initially, then increase interval N = 5 4 adults 1 child,…
Advances in Vaccine Technology
Gardasil Gardasil 9 Cervarix Gender Females and males in the USA Females and males in the USA Females Age (years) 9–26 Females 9–26 and males 9–21 9–25 Recommended age…
The Epidemiology of Recurrent Respiratory Papillomatosis
Fig. 2.1 Global reported rates of incidence and prevalence of JoRRP. Rates are per 100,000 children 2.1.1 Africa Estimates of incidence and prevalence for JoRRP have been reported for the…
Monitoring Public Health Impact of HPV Vaccination on RRP
Study Type of study Study period Onset (age) Incidence per 100,000 persons Prevalence per 100,000 persons Country/study population Lindeberg and Elbrond (1990) Population-based registry 1968–1984 Juvenile (<20 years) 0.362 – Denmark/Funen…
Human Papillomavirus Vaccination: Making Sense of the Public Controversy
© Springer International Publishing AG 2018Paolo Campisi (ed.)Recurrent Respiratory Papillomatosishttps://doi.org/10.1007/978-3-319-63823-2_5 5. Human Papillomavirus Vaccination: Making Sense of the Public Controversy Talía Malagón1 and Eduardo L. Franco1 (1) Division of Cancer Epidemiology, McGill University, 5100 Maisonneuve Blvd West,…
