AJO History of Ophthalmology Series
The search for an effective treatment for retinal detachment involved many false hypotheses and misconceived surgical techniques, even after De Wecker and Leber in 1875 and 1882 proposed that retinal…
OPHTHALMOLOGY
Reduced-Fluence Photodynamic Therapy Combined With Intravitreal Bevacizumab for Polypoidal Choroidal Vasculopathy
Purpose To evaluate the efficacy and safety of reduced-fluence photodynamic therapy (PDT) combined with bevacizumab for polypoidal choroidal vasculopathy (PCV). Design Prospective, noncomparative, interventional case series. Methods Sixteen treatment-naïve patients…
Efficacy and Potential Complications of Difluprednate Use for Pediatric Uveitis
Purpose To evaluate the clinical effect of topical difluprednate in pediatric patients for treatment of noninfectious uveitis. Design Retrospective, observational case series. Methods Twenty-six eyes of 14 pediatric patients with…
Clinical Features of Newly Diagnosed Cytomegalovirus Retinitis in Northern Thailand
Purpose To characterize the clinical manifestations of cytomegalovirus (CMV) retinitis in northern Thailand. Design Prospective, observational, cross-sectional study. Methods We recorded characteristics of 52 consecutive patients newly diagnosed with CMV…
Peripheral Exudative Hemorrhagic Chorioretinopathy: Polypoidal Choroidal Vasculopathy and Hemodynamic Modifications
Purpose To investigate choroidal vascular abnormalities in peripheral exudative hemorrhagic chorioretinopathy, using dynamic ultrawide-field fluorescein angiography (FA) and indocyanine green angiography (ICGA). Design Prospective observational case series. Methods This institutional…
Correlation Between Plasma Pentosidine Concentrations and Retinal Hemodynamics in Patients With Type 2 Diabetes
Purpose To investigate whether plasma pentosidine, a well-defined advanced glycation end product, is associated with retinal hemodynamic abnormalities in patients with type 2 diabetes. Design Prospective cross-sectional study. Methods Forty-two…
Succinate Increases in the Vitreous Fluid of Patients With Active Proliferative Diabetic Retinopathy
Purpose To examine vitreous succinate levels from proliferative diabetic retinopathy (PDR) patients and ascertain their association with PDR activity. Design Comparative case series. Methods A total of 81 eyes of…
Multimodal Fundus Imaging in Choroidal Osteoma
Purpose To describe the morphologic features of calcified and decalcified choroidal osteomas using multimodal imaging and correlate these findings with a previous histopathologic study. Design Retrospective observational case series. Methods…
Infrared Imaging and Optical Coherence Tomography Reveal Early-Stage Astrocytic Hamartomas Not Detectable by Fundoscopy
Purpose To describe and correlate the features of astrocytic hamartomas using multimodal imaging. Design Prospective, noncomparative, observational case series. Methods This was a single-center study of 4 patients (8 eyes)…
Retinal Breaks in Small-Gauge Pars Plana Vitrectomy
Purpose To determine the frequency of peripheral iatrogenic retinal breaks in eyes undergoing small-gauge pars plana vitrectomy. Design Prospective, single-center, noncomparative interventional case series. Methods A consecutive series of patients…
