Ciliary Body as a Therapeutic Target
Fig. 4.1 This is an image of the OcuLight SLx, the most commonly used ophthalmic diode laser in the United States (Image courtesy of Iridex, Mountain View, CA) Fig. 4.2…
OPHTHALMOLOGY
Suprachoroidal Space as a Therapeutic Target
Generic name Brand name in the USA Manufacturer Unoprostone Rescula CIBA Vision Ophthalmics, Bulach, Switzerland (also generically manufactured by other companies) Latanoprost Xalatan Pfizer Inc., New York, NY (also generically…
Clinical Trials for IOP-Lowering Devices to Support an FDA Premarket Submission
John R. Samples and Iqbal Ike K. Ahmed (eds.)Surgical Innovations in Glaucoma10.1007/978-1-4614-8348-9_5 © Springer Science+Business Media New York 2014 5. Clinical Trials for IOP-Lowering Devices to Support an FDA Premarket Submission Judy F. Gordon1 and Robert L. Kramm2 (1) ClinReg Consulting Services,…
Considerations in Patenting New Surgical Devices for Glaucoma: The Changing Patent Law Landscape
and Gabrielle LaHatte2 (1) Formerly an Intellectual Property Litigation Associate with Klarquist Sparkman, LLP, Portland, OR, USA (2) Formerly a Staff Attorney with Tarolli, Sundheim, Covell & Tummino, LLP, Cleveland, OH,…
Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System
(14.1) (14.2) (14.3) (14.4) (14.5) (14.6) (14.7) (14.8)Type II mechanism (14.9) (14.10) (14.11)In these mechanistic formulations, S, 1S, and 3S represent the sensitizer (S) in the ground state and in…
Corneal Epithelial Nuclear Ferritin and Its Transporter Ferritoid Afford Unique Protection to DNA from UV Light and Reactive Oxygen Species
Fig. 3.1 In our model for the protection of the DNA of CE cells from UV-induced damage the ROS, here H2O2, is produced by UV light. If free iron is…
Transforming Growth Factor: β3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts
# of up-regulated metabolites # of down-regulated metabolites 2D HCK + T3 3 20 HCF + T3 15 1 3D HCK + T3 56 3 HCF + T3 4 3 Only the metabolites passing filtering criteria were…
The Human Lens: A Living Biometric Indicator of Health Status and Successful Aging
Reprinted from [8] with permission from Dr. S. Richer There are three types of aging cataracts: nuclear, cortical, and posterior subcapsular. Nuclear cataract, the most common type, is a central…
Corneal Degenerations
Fig. 2.1 Arcus senilis. (Archives Dr. A.M. Roszkowska) Beyond senescence, the lipid arcus can be present in young males with hypercholesterolemia and hypertriglyceridemia. In fact, such association is actually considered…
Cataract in Pediatric Age Group: A Review
Fig. 22.1 (a, b) A Lamellar (Zonular) cataract Fig. 22.2 (a, b) Floriform cataract Fig. 22.3 Blue dot and sutural cataract Fig. 22.4 (a–c) Lens with showing anterior and posterior…
