Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase…
Bacterial pathogens and microbiome alterations can contribute to the initiation and propagation of mucosal inflammation in chronic rhinosinusitis (CRS). In this article, the authors review the clinical and research implications…
Our understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease’s pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside…
Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically…
An estimated 4.5% of total US health care dollars have been devoted to mitigating chronic rhinosinusitis. The most recalcitrant of these patients undergo surgery, which fails to improve symptoms in…
Abtin Tabaee, MD, Editor Edward D. McCoul, MD, MPH, Editor The past decade has witnessed a dramatic increase in the quality and volume of research into the basic science underpinnings…
Sujana S. Chandrasekhar, MD, FACS, Consulting Editor Often in medicine, what seems simple is actually very complex. That is the case with chronic rhinosinusitis (CRS). CRS is a common chronic…
Population-based cancer registries allow for data collection on the scale of large populations, outside the limits of a single institution, and facilitate study of rare entities. The SEER database has…
Key points • Sinonasal and ventral skull base malignancies are rare and this has made it difficult to conduct randomized controlled trials. Much knowledge of the clinical outcomes for these…
Cancers develop secondary to genetic and epigenetic changes that provide the cell with a survival advantage that promotes cellular immortality. Malignancy arises when tumors use mechanisms to evade detection and…
