AJO History of Ophthalmology Series
The common misconception in superficial histories of medicine is that Joseph Lister (1827—1912) singlehandedly revolutionized surgery by applying the new germ theory to the care of the surgical patient, and…
Impact of Clinical Factors on the Long-Term Functional and Anatomic Outcomes of Osteo-odonto-keratoprosthesis and Tibial Bone Keratoprosthesis
Purpose To report the long-term functional and anatomic outcomes of osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis; to analyze the influence of clinical factors, such as surgical technique, primary diagnosis, age, and…
Corneal Nerve Aberrations in Bullous Keratopathy
Purpose To study the corneal nerves in patients with chronic bullous keratopathy. Design Prospective observational case series with histologic evaluation. Methods We studied 25 eyes of 25 bullous keratopathy patients…
In Vivo Analysis of Stromal Integration of Multilayer Amniotic Membrane Transplantation in Corneal Ulcers
Purpose To evaluate integration of amniotic membrane into the corneal stroma using laser scanning in vivo confocal microscopy and anterior segment optical coherence tomography (AS-OCT). Design Prospective noncomparative interventional case…
Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study
Purpose To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns. Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of…
Amino Acid Profiles in Human Tear Fluids Analyzed by High-Performance Liquid Chromatography and Electrospray Ionization Tandem Mass Spectrometry
Purpose To identify the 23 amino acid profiles in human tear fluids, and to evaluate whether the ocular disease conditions reflect the amino acid profiles. Design Laboratory investigation. Methods We…
Screening for Dry Eye With Newly Developed Ocular Surface Thermographer
Purpose To evaluate the newly developed Ocular Surface Thermographer (TOMEY Corporation) for dry eye screening. Design Prospective, controlled study. Methods We studied 30 eyes of 30 patients diagnosed with dry…
Tear Osmolarity in the Diagnosis and Management of Dry Eye Disease
Purpose To evaluate the use of tear osmolarity in the diagnosis of dry eye disease. Design A prospective, observational case series to determine the clinical usefulness of tear osmolarity and…
Intraocular Pressure Measurements and Biomechanical Properties of the Cornea in Eyes After Penetrating Keratoplasty
Purpose To compare intraocular pressure (IOP) measurements obtained using the Goldmann applanation tonometer (GAT; Haag-Streit), the Tono-Pen XL (Reichert, Inc), and the ocular response analyzer (ORA; Reichert Ophthalmic Instruments), and…
The Lifetime Economic Burden of Keratoconus: A Decision Analysis Using a Markov Model
Purpose To estimate the expected incremental lifetime cost of treatment of keratoconus compared to the expected cost of the treatment of myopia. Design Cost estimate from the patient’s perspective using…
