Purpose To evaluate the use of tear osmolarity in the diagnosis of dry eye disease. Design A prospective, observational case series to determine the clinical usefulness of tear osmolarity and…

Purpose To compare intraocular pressure (IOP) measurements obtained using the Goldmann applanation tonometer (GAT; Haag-Streit), the Tono-Pen XL (Reichert, Inc), and the ocular response analyzer (ORA; Reichert Ophthalmic Instruments), and…

The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of…

Purpose To evaluate the long-term endothelial cell density (ECD) changes and visual and refractive outcomes after deep anterior lamellar keratoplasty (DALK) using the big-bubble technique in eyes with keratoconus. Design…

Purpose To assess the presence of transforming growth factor-β (TGFβ) pathway markers in the epithelium of keratoconus patient corneas. Design Retrospective, comparative case series of laboratory specimens. Methods Immunohistochemistry results…

Purpose To review the history of indocyanine green (ICG) angiography and to present a personal perspective on its use in the clinical setting today. Design Perspective with literature review and…

The Tube Versus Trabeculectomy (TVT) Study was designed to answer the question of whether instillation of an aqueous drainage device (tube) or a trabeculectomy (trab) should be performed on patients…

More than 25 years ago, the Branch Vein Occlusion Study (BVOS) reported the usefulness of grid pattern laser photocoagulation for perfused macular edema in eyes with branch retinal vein occlusion…