Defining Discordance Between Signs and Symptoms in Dry Eye Disease: Insights From the DRy Eye Assessment and Management (DREAM) Study

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Defining Discordance Between Signs and Symptoms in Dry Eye Disease: Insights From the DRy Eye Assessment and Management (DREAM) Study

Objective To evaluate symptom-sign discordance in dry eye disease (DED) using 3 distinct analytical frameworks in a large prospective cohort and to identify associated systemic risk factors. Design Secondary analysis…

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Prediction of 9 Artificial Intelligence-based Intraocular Lens Power Calculation Formulas in Long Caucasian Eyes

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Prediction of 9 Artificial Intelligence-based Intraocular Lens Power Calculation Formulas in Long Caucasian Eyes

PURPOSE To compare accuracy of nine artificial intelligence (AI)- based intraocular lens (IOL) power calculation formulas in eyes with axial length > 26 mm. DESIGN Retrospective accuracy and validity analysis….

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Biopsy-Only Versus Debulking Surgical Approaches for Pediatric Orbital Rhabdomyosarcoma: Impact on Eye Preservation and Oncologic Outcomes

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Biopsy-Only Versus Debulking Surgical Approaches for Pediatric Orbital Rhabdomyosarcoma: Impact on Eye Preservation and Oncologic Outcomes

PURPOSE To compare eye preservation and survival outcomes between biopsy-only and debulking surgical approaches in pediatric orbital rhabdomyosarcoma treated with contemporary multimodal therapy. METHODS Retrospective chart review of 27 patients…

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Noninfectious Posterior Uveitides — Atypicals, Variants, and Masquerades: The Jungle of Differential Diagnosis

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Noninfectious Posterior Uveitides — Atypicals, Variants, and Masquerades: The Jungle of Differential Diagnosis

Purpose Consensus efforts by the Multimodal Imaging in Uveitis (MUV) Task Force have established standardized diagnostic criteria for the major non-infectious posterior and panuveitides (NIPUs), historically referred to as “white…

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Imaging Measures for the Assessment of Disease Activity in Noninfectious Posterior Uveitis – Multimodal Imaging in Uveitis (MUV) Taskforce: Report 10

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Imaging Measures for the Assessment of Disease Activity in Noninfectious Posterior Uveitis – Multimodal Imaging in Uveitis (MUV) Taskforce: Report 10

PURPOSE To develop imaging-based measures for disease assessment in noninfectious posterior uveitis (NIPU). DESIGN A mixed-methods design, beginning with a review of previously developed imaging recommendations formulated by separate subcommittees…

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In Vitro Study of Microbial Growth in Artificial Tears Using a Novel Kinetic and Culture-Based Model

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on In Vitro Study of Microbial Growth in Artificial Tears Using a Novel Kinetic and Culture-Based Model

Purpose Artificial tears (ATs) are widely used to relieve ocular symptoms of irritation, yet their diverse formulations containing varying viscosity agents, electrolytes, osmoprotectants, oils, and surfactants may differentially support microbial…

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Optogenetic Therapy With UGX-201 in Advanced Nonsyndromic Retinitis Pigmentosa: Safety and Efficacy From an Exploratory Clinical Trial

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Optogenetic Therapy With UGX-201 in Advanced Nonsyndromic Retinitis Pigmentosa: Safety and Efficacy From an Exploratory Clinical Trial

Highlights • First optogenetic therapy trial in advanced nonsyndromic RP patients in China. • Single intravitreal UGX-201 injection demonstrated favorable safety and tolerability profile. • Clinically meaningful visual acuity improvement…

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Unilateral Retinal Pigment Epithelium Dysgenesis—The Expanded Spectrum and New Insights From Multimodal Imaging

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Unilateral Retinal Pigment Epithelium Dysgenesis—The Expanded Spectrum and New Insights From Multimodal Imaging

Purpose To describe the clinical spectrum, novel imaging features, and associations of unilateral retinal pigment epithelium dysgenesis (URPED), expanding its phenotypic and pathogenetic framework. Design Retrospective, longitudinal, multicenter case series….

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Surgical Outcomes in Partially Accommodative Esotropia Using Augmented Distance-Angle Averaging With and Without Hyperopic Correction

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Surgical Outcomes in Partially Accommodative Esotropia Using Augmented Distance-Angle Averaging With and Without Hyperopic Correction

Purpose Undercorrection is common after standard dosing of medial rectus (MR) recession for partially accommodative esotropia (PAET). Our goal was to evaluate motor and sensory outcomes in patients with PAET…

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Hyperreflective Foci Contiguous With the Retinal Pigment Epithelium Associated With Visual Function in Aging, Early, and Intermediate Age-Related Macular Degeneration: MACUSTAR Study Report

Sep 20, 2026 by drzezo in OPHTHALMOLOGY Comments Off on Hyperreflective Foci Contiguous With the Retinal Pigment Epithelium Associated With Visual Function in Aging, Early, and Intermediate Age-Related Macular Degeneration: MACUSTAR Study Report

PURPOSE To evaluate the association of hyperreflective foci contiguous with the retinal pigment epithelium (rpeHRF) with visual function impairment in aged normals, early age-related macular degeneration (eAMD), and intermediate AMD…

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