FIGURE 23.1. A: Intense angiogenesis leads to a plexus of vessels with shunts and saccular dilations. B: Antiangiogenic therapy can lead to a pruning of vessels, particularly those that are…
Macular Edema P.S. Silva • Z.A. Haddad • J.K. Sun • J.D. Cavallerano • L.P. Aiello Introduction For the past 20 years, diabetic retinopathy (DR) has remained the most common…
FIGURE 9.1. Schematic diagram showing how diabetes in conjunction with hypertension and hyperlipidemia causes alteration of the BRB, leading to DME. Both increased levels of growth factors and proteinases, as…
Pathologic neovascularization occurs in various ocular tissues, including the cornea, iris, retina, and choroid Tissue Disease/Trauma Cornea Contact lens injury Trauma/alkali injury Infectious keratitis (trachoma) Iris Enucleation (i.e., retinoblastoma) Central…
FIGURE 30.1. The role of platelet-derived growth factor (PDGF)-B on blood vessel growth and mural cell coverage in a corneal neovascularization model. A: Endothelial cells were labeled by staining with…
Results: Photocoagulation prevented severe vision loss by 50% in PDR patients (at 4 years, 20% risk in treated eyes versus 44% risk in untreated eyes with HRC). The beneficial effect…
Neovascular-AMD Currently in Clinical Trials Mohamed Ibrahim • Roomasa Channa • Diana V. Do • Quan Dong Nguyen INTRODUCTION The prevalence of advanced stages of age-related macular degeneration (AMD) in…
FIGURE 5.1. Effect of GH inhibition on ischemia-induced retinal neovascularization. A: Cross section of an eye from a nontransgenic littermate mouse, showing retinal neovascularization internal to the inner limiting membrane…
of Anti-angiogenic Drugs George A. Williams INTRODUCTION The advent of anti–vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration has prevented blindness in tens of thousands of people….
Pathophysiology Mark E. Kleinman • Jayakrishna Ambati Introduction The chorioretinal architecture is a heterogeneous assembly of specialized tissues derived from neuroectoderm and mesenchyme. The dual-layered blood-retina barrier, which incorporates the…
