Retinal Neovascularization Jason Hsu • Allen C. Ho Introduction Until recently, laser panretinal photocoagulation (PRP) has been the standard for treatment of patients with proliferative diabetic retinopathy (PDR) in order…
Endothelium Growth FactorPharmacological Agents Leanne T. Labriola • Muge Kesen • Karl G. Csaky Introduction Revascularization is a serious sequela of ocular diseases including age-related macular degeneration, diabetic retinopathy, vascular…
in the Management of Age-Related MacularDegeneration and Macular Edema Pearse A. Keane • Srinivas R. Sadda INTRODUCTION TO OPTICAL COHERENCE TOMOGRAPHY Optical coherence tomography (OCT), first described by Huang et…
FIGURE 25.1. Algorithm regarding the management of neovascular glaucoma. CAUSES OF ANTERIOR CHAMBER NEOVASCULARIZATION While many pathologic ocular processes can initiate fibrovascular proliferation, ischemic retinal disease is the most common…
Beneficial, Innately Complicated Matthew Neu • Ashay Bhatwadekar • Reinhold Medina • Alan Stitt • Maria Grant INTRODUCTION The notion of using endothelial progenitors to repair vasodegenerative vasculature in diabetic…
Segment: Challenges Prithvi Mruthyunjaya In proangiogenic diseases such as neovascular age-related macular degeneration (ARMD) and diabetic retinopathy (DR), there is growing interest in delivery of targeted therapeutic agents to the…
Anti-Vegf Therapy The FDA approval of anti-VEGF therapy for the treatment of exudative ARMD has heralded a new era for the management of this devastating disease, offering patients and their…
Neovascularization Robert N. Frank INTRODUCTION The human retinal vasculature is essentially complete at birth in the full-term infant. These vessels elongate with growth of the eye through childhood and adolescence,…
Results: At the month 24 examination for the primary outcome, 53% of verteporfin-treated patients compared with 38% placebo-treated patients lost fewer than 15 letters. In subgroup analyses for predominantly classic…
FIGURE 4.1. Summary diagram of VEGF expression in the developing retina. (Reprinted from Stone et al. J Neurosci. 1995;15:4738–4747, with permission.) In addition to the well-studied transcriptional induction of VEGF…
