Part 4 The role of electrophysiology and psychophysics in ocular toxicology Eberhart Zrenner MD Introduction Modern structure-based drug design results increasingly in compounds that act very specifically, e.g. as modulators…
Part 2 Ocular drug delivery and toxicology Frederick T. Fraunfelder MD Drug delivery to the eye is a complex process. The eye is unique in the body in many ways…
Part 1 Principles of therapy Focke Ziemssen MD, Manfred Zierhut MD Pharmacodynamics “Pharmacodynamics” can be defined as the quantitative relationship between the observed tissue concentration of the active drug and…
Systemic administration Certain 1. Blurred vision 2. Eyelids or conjunctiva a. Erythema b. Conjunctivitis – nonspecific c. Edema d. Urticaria 3. Visual hallucinations Probable 1. Aggravate keratoconjunctivitis sicca Conditional/unclassified 1….
Part 7 Drug-induced ocular side effects Section 1. Anti-infectives Class: Amebicides Generic Names: 1. Broxyquinoline; 2. diiodohydroxyquinoline (iodoquinol). Proprietary Names: 1. Starogyn; 2. Sebaquin, Yodoxin. Primary use These amebicidal agents…
Generic Name: Naproxen. Fincham JE. Exacerbation of glaucoma in an elderly female taking naproxen sodium: a case report. J Geriatr Drug Ther. 1989;3:139–143. Fraunfelder FT. Interim report: National Registry of…
Generic Name: Naproxen. Fincham JE. Exacerbation of glaucoma in an elderly female taking naproxen sodium: a case report. J Geriatr Drug Ther. 1989;3:139–143. Fraunfelder FT. Interim report: National Registry of…
Part 8 Herbal medicine and dietary supplement–induced ocular side effects Frederick W. Fraunfelder MD Herbal or Supplement Names: 1. Aluminum nicotinate; 2. niacin (nicotinic acid); 3. niacinamide (nicotinamide); 4. nicotinyl…
Possible aggravated keratoconjunctivitis sicca Possible 1. Eyelids or conjunctiva a. Exfoliative dermatitis b. Contact dermatitis Topical – glycopyrrolate cream Probable 1. Mydriasis 2. Decreased accommodation Local ophthalmic use or exposure…
Systemic administration Certain 1. Reduction or inhibition of fibrosis a. Delays wound healing b. Enhances filtration surgery success Probable 1. Inhibition of mitosis and migration of epithelial cells with delayed…
