Gene Therapy
Gene Vector Recipient animal References Catalase AdV Guinea pig [32] Atoh1 AdV Guinea pig [4, 35] Atoh1 AdV Mouse [36, 37] GDNF/TGFbeta AdV Guinea pig [31] NOX3 (siRNA) Rat [34]…
Dedifferentiation-Mediated Regeneration
Fig. 22.1 Overview of dedifferentiation-mediated hair cell regeneration. Dedifferentiation-mediated hair cell regeneration involves a dedifferentiation step (dashed arrow) and a subsequent redifferentiation step (arrow). iPS transcription factors (TFs) and epigenetic…
Self-Repair
Fig. 20.1 Summary of critical events and therapeutic drugs after hair cell damage in the apoptotic process. Just after hair cell damage, ROS and JNK are activated. Several hours later,…
Regenerative Medicine in Cochlear Implantation
Fig. 16.1 Schematic representation of the targets and methods for the regenerative medicine in cochlear implantation. The electrode of cochlear implant was placed in the scala tympani. Neurotrophic factors, stem…
Cochlear Implant: Past, Present, and Future
Fig. 14.1 Tonotopic organization in the cochlea and the cochlear nucleus. Black, dark gray, and light gray lines represent high, middle, and low frequencies, respectively. In the cochlea, a simple…
Synaptic Contacts Between Hair Cells and Primary Neurons
Fig. 7.1 Hair cell synapses in the cochlea [2] Synaptic ribbons are electron-dense structures that are located at the base of hair cells and play a role as a pool…
Cochlear Lateral Wall
Fig. 5.1 Cochlear lateral wall and potassium ion recycling. The ionic composition with high potassium concentration and endocochlear potential are maintained by ion transport through the cochlear lateral wall. Potassium…
Development and Regeneration
Fig. 10.1 Induction of stem cells or transdifferentiation requires developmentally important factors that regulate process of differentiation, migration, proliferation, and apoptosis 10.2 Pluripotent Stem Cells and Development Induction of pluripotent…
Tectorial Membrane
Fig. 9.1 (a) The schema showing the morphological relationship between the organ of Corti and TM. The limbal zone is the lesion where TM is attached to the spiral limbus,…
Spiral Ganglion Cell and Auditory Neuron
Fig. 6.1 Schematic illustration showing the anatomical relationships between the auditory nerve (AuN) and the surrounding structures. The auditory nerve is a bundle of bipolar neurons that form synaptic contacts…
