Gene Therapy

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Gene Therapy

Gene Vector Recipient animal References Catalase AdV Guinea pig [32] Atoh1 AdV Guinea pig [4, 35] Atoh1 AdV Mouse [36, 37] GDNF/TGFbeta AdV Guinea pig [31] NOX3 (siRNA) Rat [34]…

read more

Dedifferentiation-Mediated Regeneration

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Dedifferentiation-Mediated Regeneration

Fig. 22.1 Overview of dedifferentiation-mediated hair cell regeneration. Dedifferentiation-mediated hair cell regeneration involves a dedifferentiation step (dashed arrow) and a subsequent redifferentiation step (arrow). iPS transcription factors (TFs) and epigenetic…

read more

Self-Repair

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Self-Repair

Fig. 20.1 Summary of critical events and therapeutic drugs after hair cell damage in the apoptotic process. Just after hair cell damage, ROS and JNK are activated. Several hours later,…

read more

Regenerative Medicine in Cochlear Implantation

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Regenerative Medicine in Cochlear Implantation

Fig. 16.1 Schematic representation of the targets and methods for the regenerative medicine in cochlear implantation. The electrode of cochlear implant was placed in the scala tympani. Neurotrophic factors, stem…

read more

Cochlear Implant: Past, Present, and Future

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Cochlear Implant: Past, Present, and Future

Fig. 14.1 Tonotopic organization in the cochlea and the cochlear nucleus. Black, dark gray, and light gray lines represent high, middle, and low frequencies, respectively. In the cochlea, a simple…

read more

Cochlear Lateral Wall

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Cochlear Lateral Wall

Fig. 5.1 Cochlear lateral wall and potassium ion recycling. The ionic composition with high potassium concentration and endocochlear potential are maintained by ion transport through the cochlear lateral wall. Potassium…

read more

Development and Regeneration

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Development and Regeneration

Fig. 10.1 Induction of stem cells or transdifferentiation requires developmentally important factors that regulate process of differentiation, migration, proliferation, and apoptosis 10.2 Pluripotent Stem Cells and Development Induction of pluripotent…

read more

Tectorial Membrane

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Tectorial Membrane

Fig. 9.1 (a) The schema showing the morphological relationship between the organ of Corti and TM. The limbal zone is the lesion where TM is attached to the spiral limbus,…

read more

Spiral Ganglion Cell and Auditory Neuron

Mar 26, 2017 by in OTOLARYNGOLOGY Comments Off on Spiral Ganglion Cell and Auditory Neuron

Fig. 6.1 Schematic illustration showing the anatomical relationships between the auditory nerve (AuN) and the surrounding structures. The auditory nerve is a bundle of bipolar neurons that form synaptic contacts…

read more
Get Clinical Tree app for offline access