Novel Topical Therapeutics
Intranasal drug delivery is a rapidly growing field that offers the potential for enhanced treatment of local and systemic disease. Novel preclinical screening tools such as in vitro assays and…
The Role of Fungus in Chronic Rhinosinusitis
Fungus has been cited as an etiologic factor (the etiologic factor?) in chronic rhinosinusitis (CRS), and a vigorous debate has ensued. Initial reports of in vitro observations promoted fungus as…
Superantigens
Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune…
Local and Systemic IgE in the Evaluation and Treatment of Allergy
Traditional descriptions of type I hypersensitivity and its manifestations center on systemic immunoglobulin E (IgE)-mediated reactions to inciting antigens. Hence, many current diagnostic and therapeutic measures are based on systemic…
Cilia Dysfunction
Cilia are complex and powerful cellular structures that serve a multitude of functions across many types of organisms. In humans, one of the most critical roles of cilia is defense…
