Randomized Study of Bevacizumab vs Ranibizumab for Age-Related Macular Degeneration: Inappropriate Conclusions
Subramanian and associates report that their randomized controlled trial originally was powered on the basis of an overall sample size of 135 patients (90 in the bevacizumab group and 45…
A Novel Locus for Autosomal Recessive Retinitis Pigmentosa in a Consanguineous Pakistani Family Maps to Chromosome 2p
Objective To identify a disease locus for autosomal recessive retinitis pigmentosa in a consanguineous Pakistani family. Design Prospective linkage study. Methods Blood samples were collected and genomic DNA was extracted….
Influence of the Extent of Myopia on the Progression of Normal-Tension Glaucoma
Purpose To evaluate the influence of the extent of myopia on the progression rate of normal-tension glaucoma (NTG). Design Retrospective, observational case series. Methods One hundred forty-three eyes of 143…
The Assessment of Disability Related to Vision Performance-Based Measure in Diabetic Retinopathy
Purpose To validate a third-generation performance-based measure of visual function titled “Assessment of Disability Related to Vision” (ADREV) in a study population of patients with diabetic retinopathy. Design Prospective, cross-sectional…
Estrogen Receptor Beta Gene Polymorphism and Intraocular Pressure Elevation in Female Patients With Primary Open-Angle Glaucoma
Purpose To assess whether the genetic polymorphisms of estrogen receptor beta ( ESR2 ) are associated with primary open-angle glaucoma (POAG). Design Case-control study. Methods Four hundred and twenty-five Japanese…
Topical Mecamylamine for Diabetic Macular Edema
Purpose Stimulation of nicotinic acetylcholine (nACh) receptors on vascular endothelial cells promotes angiogenesis and vascular permeability in animal models. The safety and bioactivity of topical mecamylamine, an antagonist of nACh…
Structure–Function Correlations Using Scanning Laser Polarimetry in Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma
Purpose To assess the correlations between retinal nerve fiber layer (RNFL) thickness measured with scanning laser polarimetry and visual field (VF) sensitivity in primary open-angle glaucoma (POAG) and primary angle-closure…
AJO History of Ophthalmology Series
Meyer-Schwickerath survived World War II serving as a paramedic; then a knee injury kept him from going to the front. Obtaining his medical degree soon after the end of the…
Association Between Abnormal Contrast Sensitivity and Mortality Among People With Acquired Immunodeficiency Syndrome
Purpose To investigate the relationship between contrast sensitivity (CS) and mortality among people with acquired immunodeficiency syndrome (AIDS); and to explore the hypothesis that abnormal CS is a marker of…
