Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis

18.
Sanwal M, Muel AS, Chaudun E, Courtois Y, Counis MF. Chromatin condensation and terminal differentiation process in embryonic chicken lens in vivo and in vitro. Exp Cell Res. 1986;167:429–39.PubMedCrossRef
19.
McAvoy JW, Chamberlain CG. Growth factors in the lens. Prog Growth Factor Res. 1990;2:29–43.PubMedCrossRef
20.
Lang RA. Which factors stimulate lens fiber cell differentiation in vivo? Invest Ophthalmol Vis Sci. 1999;40:3075–8.PubMed
21.
Chow RL. Early eye development in vertebrates. Annu Rev Cell Dev Biol. 2001;17:255–96.PubMedCrossRef
22.
Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW. Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Mol Vis. 2008;14:762–73.PubMedCentralPubMed
23.
Li DW-C, Xiang H, Fass U, Zhang X-Y. Analysis of expression patterns of protein phosphatase-1 and phosphatase-2A in rat and bovine lenses. Invest Ophthalmol Vis Sci. 2001;42:2603–9.PubMed
24.
Liu WB, Yan Q, Liu FY, Tang XC, Chen HG, Liu J, Nie L, Zhang XW, Ji WK, Hu XH, Hu WF, Woodward Z, Wu KL, Wu MX, Liu XL, Luo LX, Yu MB, Liu YZ, Liu SJ, Li DW. Protein serine/threonine phosphotase-1 is essential in governing normal development of vertebrate eye. Curr Mol Med. 2012;12:1361–71.PubMedCrossRef
25.
Yan Q, Liu WB, Qin J, Liu J, Chen HG, Huang X, Chen L, Sun S, Deng M, Gong L, Li Y, Zhang L, Liu Y, Feng H, Xiao Y, Liu Y, Li DW. Protein phosphatase-1 dephosphorylates Pax-6, a transcription factor controlling brain and eye development. J Biol Chem. 2007;282(19):13954–65.PubMedCrossRef
26.
Ludlow JW, Glendening CL, Livingston DM, DeCarprio JA. Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol. 1993;13:367–72.PubMedCentralPubMed
27.
Xiao L, Gong LL, Yuan D, Deng M, Zeng XM, Chen LL, Zhang L, Yan Q, Liu JP, Hu XH, Sun SM, Liu J, Ma HL, Zheng CB, Fu H, Chen PC, Zhao JQ, Xie SS, Zou LJ, Xiao YM, Liu WB, Zhang J, Liu Y, Li DW. Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation. Cell Death Differ. 2010;17(9):1448–62.PubMedCrossRef
28.
Li DW, Fass U, Huizar I, Spector A. Okaidac acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax. Eur J Biochem. 1998;257:351–61.PubMedCrossRef
29.
Li DW, Liu JP, Schmid PC, Schlosser R, Feng H, Liu WB, Yan Q, Gong L, Sun SM, Deng M, Liu Y. Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene. 2006;25:3006–22.PubMedCrossRef
30.
Yan Q, Liu J-P, Li DW-C. Apoptosis in the ocular lens: role in development and pathogenesis. Differentiation. 2006;74:195–211.PubMedCrossRef
31.
Zhang L, Yan Q, Liu JP, Zou LJ, Liu J, Sun S, Deng M, Gong L, Ji WK, Li DW. Apoptosis: its functions and control in the ocular lens. Curr Mol Med. 2010;10(9):864–75.PubMedCrossRef
32.
Hu WF, Gong L, Cao Z, Ma H, Ji W, Deng M, Liu M, Hu XH, Chen P, Yan Q, Chen HG, Liu J, Sun S, Zhang L, Liu JP, Wawrousek E, Li DW. αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Curr Mol Med. 2012;12(2):177–87.PubMedCrossRef
33.
Glucksmann A. Cell deaths in normal vertebrate ontogeny. Biol Rev. 1951;26:59–86.PubMedCrossRef
34.
Silver J, Hughes AFW. The role of cell death during morphogenesis of the mammalian eye. J Morphol. 1973;140:159–70.PubMedCrossRef
35.
Ishizaki Y, Voyvodic JT, Burne JF, Raff MC. Control of lens epithelial cell survival. J Cell Biol. 1993;121:899–908.PubMedCrossRef
36.
Ozeki H, Ogura Y, Hirabayashi Y, Shimada S. Suppression of lens stalk cell apoptosis by hyaluronic acid leads to faulty separation of the lens vesicle. Exp Eye Res. 2001;72:63–70.PubMedCrossRef
37.
Bozanic D, Tafra R, Saraga-Babic M. Role of apoptosis and mitosis during human eye development. Eur J Cell Biol. 2003;82:421–9.PubMedCrossRef
Mar 31, 2017 | Posted by in OPHTHALMOLOGY | Comments Off on Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access