Dikstein S, Maurice DM. The active control of corneal hydration. Isr J Med Sci. 1972;8:1523–8.PubMed

Brown DI, Griendling KK. Nox proteins in signal transduction. Free Radic Biol Med. 2009;47:1239–53.PubMedCentralPubMed

Gillespie MN, Pastukh V, Ruchko MV. Oxidative DNA modifications in hypoxic signaling. Ann N Y Acad Sci. 2009;1177:140–50.PubMed

Shin YJ, Cho DY, Chung TY, Han SB, Hyon JY, Wee WR. Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells. Curr Eye Res. 2011;36(12):1116–22.PubMed

Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ. Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res. 2006;3:327–37.

Nishi Y, Engler C, Na DR, Kashiwabuchi RT, Shin YJ, Cano M, Jun AS, Chuck RS. Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy. Acta Ophthalmol. 2010;88(8):e323–7.PubMed

Shin YJ, Nishi Y, Engler C, Kang J, Hashmi S, Jun AS, Gehlbach PL, Chuck RS. The effect of phacoemulsification energy on the redox state of cultured human corneal endothelial cells. Arch Ophthalmol. 2009;127:435–41.PubMed

Augustin AJ, Dick HB. Oxidative tissue damage after phacoemulsification: influence of ophthalmic viscosurgical devices. J Cataract Refract Surg. 2004;30:424–7.PubMed

Shin YJ, Tata DB, Waynant RE, Gehlbach PL, Chuck RS. Fluorometric determination of the redox state and distribution of mitochondria in human malignant glioblastoma cells grown on different culturing substrates. Photomed Laser Surg. 2010;28 Suppl 1:S105–10.PubMed

del V Cano M, Reyes JM, Park CY, et al. Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci. 2008;49(6):2606–12.PubMed

Huang S, Heikal AA, Webb WW. Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. Biophys J. 2002;82(5):2811–25.PubMedCentralPubMed

Shimmura S, Tsubota K, Oguchi Y, Fukumura D, Suematsu M, Tsuchiya M. Oxiradical-dependent photoemission induced by a phacoemulsification probe. Invest Ophthalmol Vis Sci. 1992;33(10):2904–7.PubMed

Holst A, Rolfsen W, Svensson B, Ollinger K, Lundgren B. Formation of free radicals during phacoemulsification. Curr Eye Res. 1993;12(4):359–65.PubMed

Cameron MD, Poyer JF, Aust SD. Identification of free radicals produced during phacoemulsification. J Cataract Refract Surg. 2001;27(3):463–70.PubMed

Takahashi H, Sakamoto A, Takahashi R, Ohmura T, Shimmura S, Ohara K. Free radicals in phacoemulsification and aspiration procedures. Arch Ophthalmol. 2002;120(10):1348–52.PubMed

Ricci JE, Gottlieb RA, Green DR. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol. 2003;160(1):65–75.PubMedCentralPubMed

Fleury C, Mignotte B, Vayssière JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie. 2002;84(2–3):131–41.PubMed

Finger PT. Radiation therapy for orbital tumors: concepts, current use, and ophthalmic radiation side effects. Surv Ophthalmol. 2009;54:545–68.PubMed

Kiuchi T, Tatsuzaki H, Wakabayashi T, Okamoto F, Kaji Y, Oshika T. Long-term changes in rabbit cornea after ionizing radiation. Cornea. 2004;23:S87–90.PubMed

Kiuchi T, Tatsuzaki H, Hommura S, Oshika T. Specular microscopic study of X-ray-irradiated rabbit cornea. Eye (Lond). 2004;18:929–34.

Blodi FC. The effects of experimental x-radiation on the cornea. Arch Ophthalmol. 1960;63:20–9.PubMed

Jooyandeh F, Moore JS, Morgan RE, Phillips GO. Chemical effects of gamma-irradiation of aqueous solutions of heparin and keratan sulphate. Radiat Res. 1971;45:455–61.PubMed

Beutel J, Schroder C, von Hof K, Kosmehl H, Wedel T, Sieg P, et al. Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model. Graefes Arch Clin Exp Ophthalmol. 2007;245:1347–55.PubMed

Fard-Esfahani A, Mirshekarpour H, Fallahi B, Eftekhari M, Ekhari M, Saghari M, et al. The effect of high-dose radioiodine treatment on lacrimal gland function in patients with differentiated thyroid carcinoma. Clin Nucl Med. 2007;32:696–9.PubMed

Solans R, Bosch JA, Galofré P, Porta F, Roselló J, Selva-O’Callagan A, et al. Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy. J Nucl Med. 2001;42:738–43.PubMed

Bigsby RM, Valluri S, Lopez J, Mendonca MS, Caperell-Grant A, DesRosiers C, et al. Ovarian hormone modulation of radiation-induced cataractogenesis: dose-response studies. Invest Ophthalmol Vis Sci. 2009;50:3304–10.PubMed

Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78:547–81.PubMed

Sohal RS. Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med. 2002;33:37–44.PubMed

Shin YJ, Seo JM, Chung TY, Hyon JY, Wee WR. Effect of cysteamine on oxidative stress-induced cell death of human corneal endothelial cells. Curr Eye Res. 2011;36:910–7.PubMed

Rosenberg ME, Silkensen J. Clusterin: physiologic and pathophysiologic considerations. Int J Biochem Cell Biol. 1995;27:633–45.PubMed

Dumont P, Chainiaux F, Eliaers F, Petropoulou C, Remacle J, Koch-Brandt C, Gonos ES, Toussaint O. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide. Cell Stress Chaperones. 2002;7(1):23–35.PubMedCentralPubMed

Shin YJ, Kim JH, Seo JM, Lee SM, Hyon JY, Yu YS, Wee WR. Protective effect of clusterin on oxidative stress-induced cell death of human corneal endothelial cells. Mol Vis. 2009;15:2789–95.PubMedCentralPubMed

Tunon MJ, Sanchez-Campos S, Gutierrez B, Culebras JM, Gonzalez-Gallego J. Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. Biochem Pharmacol. 2003;66:439–45.PubMed

Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H. Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells. Cancer Chemother Pharmacol. 2011;67(5):1129–36.PubMed

Huang B, Blanco G, Mercer RW, Fleming T, Pepose JS. Human corneal endothelial cell expression of Na+, K + -adenosine triphosphatase isoforms. Arch Ophthalmol. 2003;121:840–5.PubMed

Ng LE, Halliwell B, Wong KP. Nephrotoxic cell death by diclofenac and meloxicam. Biochem Biophys Res Commun. 2008;369:873–7.PubMed

Schulz JB, Lindenau J, Seyfried J, Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem. 2000;267:4904–11.PubMed

Thiele K, Bierhaus A, Autschbach F, et al. Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn’s disease. Gut. 1999;45:693–704.PubMedCentralPubMed

Maher P. The effects of stress and aging on glutathione metabolism. Ageing Res Rev. 2005;4:288–314.PubMed

Dickinson DA, Forman HJ. Glutathione in defense and signaling. Ann N Y Acad Sci. 2002;973:488–504.PubMed

Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res. 1999;31:273–300.PubMed

Kofman AE, McGraw MR, Payne CJ. Rapamycin increases oxidative stress response gene expression in adult stem cells. Aging (Albany NY). 2012;4(4):279–89.

Dutta D, Xu J, Kim JS, Dunn Jr WA, Leeuwenburgh C. Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Autophagy. 2013;9(3):328–44.PubMedCentralPubMed

Pisoni RL, Park GY, Velilla VQ, Thoene JG. Detection and characterization of a transport system mediating cysteamine entry into human fibroblast lysosomes. Specificity for aminoethylthiol and aminoethylsulfide derivatives. J Biol Chem. 1995;270:1179–84.PubMed

De Biaggi CP, Barros PS, Silva VV, Brooks DE, Barros SB. Ascorbic acid levels of aqueous humor of dogs after experimental phacoemulsification. Vet Ophthalmol. 2006;9:299–302.PubMed

Gahl WA, Thoene JG, Schneider JA. Cystinosis: a disorder of lysosomal membrane transport. In: Scriver CR, Beaudet al, Sly WS, et al., editors. The metabolic & molecular bases of inherited disease, vol. 3. 8th ed. New York: McGraw Hill; 2001. p. 5085–108.

Jones NP, Postlethwaite RJ, Noble JL. Clearance of corneal crystals in nephropathic cystinosis by topical cysteamine 0–5%. Br J Ophthalmol. 1991;75:311–2.PubMedCentralPubMed

Tavares R, Coelho D, Macario MC, Torres A, Quadrado MJ, Murta J. Evaluation of treatment with cysteamine eyedrops for cystinosis with confocal microscopy. Cornea. 2009;28:938–40.PubMed

Kessler A, Biasibetti M, da Silva Melo DA, Wajner M, Dutra-Filho CS, de Souza Wyse AT, Wannmacher CM. Antioxidant effect of cysteamine in brain cortex of young rats. Neurochem Res. 2008;33:737–44.PubMed

Maher P, Lewerenz J, Lozano C, Torres JL. A novel approach to enhancing cellular glutathione levels. J Neurochem. 2008;107:690–700.PubMedCentralPubMed

Dominy Jr JE, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. J Biol Chem. 2007;282:25189–98.PubMed

Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal. 1999;11:1–14.PubMed

Cross AR, Jones OT. Enzymic mechanisms of superoxide production. Biochim Biophys Acta. 1991;1057:281–98.PubMed

Panda A, Vanathi M, Kumar A, Dash Y, Priya S. Corneal graft rejection. Surv Ophthalmol. 2007;52:375–96.PubMed

Des Marchais B, Bazin R, Boisjoly HM, Laughrea PA, Dubé I, Lille S, Roy R. Role of presensitization and donor-recipient crossmatching in corneal graft outcome. Cornea. 1998;17:141–5.PubMed

Jonas JB, Rank RM, Budde WM. Immunologic graft reactions after allogenic penetrating keratoplasty. Am J Ophthalmol. 2002;133:437–43.PubMed

Streilein JW. Anterior chamber associated immune deviation: the privilege of immunity in the eye. Surv Ophthalmol. 1990;35:67–73.PubMed

Levenson JE, Brightbill FS. Endothelial rejection in human transplants. Arch Ophthalmol. 1973;89:489–92.PubMed

Coster DJ, Williams KA. The impact of corneal allograft rejection on the long-term outcome of corneal transplantation. Am J Ophthalmol. 2005;140:1112–22.PubMed

Morris RE, Wu J, Shorthouse R. A study of the contrasting effects of cyclosporine, FK 506, and rapamycin on the suppression of allograft rejection. Transplant Proc. 1990;22:1638–41.PubMed