52.1 Type 1 MEN

• Hyperplasia of all four parathyroid glands

• Pancreatic islet tumours (including gastrinoma, insulinoma, glucagonoma, vasoactive intestinal peptide (VIP) tumour (VIPoma), or pancreatic polypeptide–producing tumour [PPoma])

• Anterior pituitary tumours (including prolactinoma, somatotropinoma, corticotropinoma, or non-functioning tumours)

• Other associated cutaneous tumours, including lipomas, angiofibromas, hypopigmented collagenomas

• 1 in 30,000 incidence

• Typically present in 2nd decade but diagnosis may be delayed for many years

• Cutaneous tumours may present first

• May be family history of skin lesions