47 Diseases of the Oral Cavity and Oropharynx • Measles—Koplik spots • Varicella zoster virus (VZV) (chickenpox)—vesicles • Behçet syndrome • Reiter syndrome • Granulomatosis with polyangiitis • Erythema multiforme • Pemphigus/pemphigoid (Fig. 47.1) • Kawasaki disease (mucocutaneous lymph node syndrome) • Sjögren syndrome • SLE • Vitamin C deficiency (scurvy) • Vitamin B2 deficiency • Vitamin B12/folate deficiency • Thrombocytopaenia • Polycythemia • Leukaemia • Herpangia • Hand-foot-and-mouth disease • Herpes simplex – Sunlight – Fever – Bacterial infections – Stress – Immunodeficiency – Other systemic illness • Herpes zoster (VZV)
47.1 Oral Manifestations of Systemic Diseases
47.1.1 Infections
47.1.2 Inflammatory Disorders
Rare
Recurrent oral and genital ulcers
Ocular inflammation
Uncommon
Urethritis
Uveitis
Conjunctivitis
Arthritis
Tongue ulcers may be mistaken for geographic tongue
Gingival hyperplasia
Lingual, palatal, and buccal ulcers also common
Multiple erosions of lip and tongue
Autoimmune vesicobullous disorders
90% of pemphigus patients will have oral cavity involvement
Strawberry tongue
Dry fissured lips
Pharyngeal injection
Necrotizing pharyngitis
Keratoconjunctivitis
Xerostomia—ulcers of tongue, lips, and buccal mucosa
Arthritis
Xerostomia
Petechiae, haemorrhagic bullae, and white keratotic plaques on tongue and oral mucosa
47.1.3 Miscellaneous Disorders
Swollen red gingival ulcerative oral petechiae ± haemorrhage
Stomatitis
Glossitis
Angular chelitis
Oral burning
Recurrent oral ulcers
Painful atrophy of oral mucosa and tongue
Necrotizing ulcerative gingivitis
Angular chelitis
Petechiae ecchymoses and haemorrhages
Purple-blue discolouration of tongue and gums
Gingival hypertrophy
47.2 Infections
47.2.1 Viral Infections
Coxsackie viruses
Multiple small vesicles and superficial ulcers—posterior oropharynx
Coxsackie A virus
Anterior oral cavity
Either primary or recurrent secondary
Common in preschool children
Diffuse bilateral lymphadenopathy common
Painful ulceration
Precipitating factors for recurrent type:
Lesions along V2 and V3
Uncommon in infants and children
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