We warmly thank the authors for their correspondence regarding our article entitled “Macular Ganglion Cell Complex and Retinal Nerve Fiber Layer Comparison in Different Stages of Age-Related Macular Degeneration.” We agree with them about the technical problems concerning how the examination was carried out and the interpretation of the results.
Another major limitation of all the investigations involving ganglion cell complex and retinal nerve fiber layer is related to the limited number of eyes analyzed by each study. Nevertheless, we feel that this topic is extremely important. In particular, the identification of a partial inner retinal sparing in the atrophic age-related macular degeneration subform can open the road to new therapeutic approaches: on the one hand diminishing the degenerative processes, and on the other leading to a potentially separate rehabilitative pathway. Further studies are warranted to ascertain the effects of current anti–vascular endothelial growth factor therapies on the inner retina layers. In essence, the long-neglected inner retina deserves to be thoroughly investigated even in age-related macular degeneration in an attempt to find new therapeutic options.