Punctate inner choroidopathy (PIC) is an idiopathic inflammatory disorder of the eye, which is more commonly affecting young myopic females. The etiology of this condition remains unknown. Patients usually develop yellow-white chorioretinal lesions at the level of the inner choroid and retinal pigment epithelium in the absence of intraocular inflammation. The condition is typically bilateral but asymmetric.

The exact incidence and prevalence of PIC is unknown as this a relatively uncommon ocular inflammatory disorder. In a case series from Moorfields Hospital in London with 136 patients diagnosed with PIC over a 16 year period, 93 % of the patients were female with a mean age at initial presentation of 32 and 84 % were myopes [1].

The etiology of the condition remains unknown although there are multiple postulated theories. Some researchers have suggested that PIC is a limited variant of myopic degeneration, as it occurs more commonly in myopic females. In the original series by Watzke et al. [2] myopia ranged from −3.25 to −10 diopters. Others have proposed that PIC represents a mild form of multifocal choroiditis. Tiedman et al. [3] theorized that there may be an association with Epstein–Barr virus infection and the development of the disorder. An autoimmune etiology has similarly been considered given an association with the development of PIC and the serotype HLA-DR2 [4], and there have been familial case reports involving mother–daughter who are affected [5].