Ocular Toxocariasis




© Springer International Publishing AG 2017
George N. Papaliodis (ed.)Uveitis10.1007/978-3-319-09126-6_13


13. Ocular Toxocariasis



Sonia Utley  and George N. Papaliodis 


(1)
Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

(2)
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA

 



 

Sonia Utley (Corresponding author)



 

George N. Papaliodis



Keywords
ToxocariasisRoundwormsUveitisOcular toxocariasis



Introduction


Toxocariasis is an infection caused by the parasitic roundworms commonly found in the intestines of dogs (Toxocara canis) and cats (Toxocara cati). A US study in 1996 demonstrated that 30 % of dogs younger than 6 months deposit Toxocara eggs in their feces; each worm releases 200,000 eggs per day. Once released in the stool, the eggs require 2–4 weeks to develop and become infectious. Toxocara embryonic eggs have a tough shell which lengthens their viability once in the stool. If these eggs are subsequently ingested, larvae hatch in the small intestine, then continue through the intestinal wall, entering the bloodstream and migrating to muscles, lungs, liver, central nervous system, and the eyes. Often the infections are asymptomatic however the two most common syndromes are systemic toxocariasis (visceral larva migrans) and ocular toxocariasis (ocular larva migrans). The severity of the organ damage depends upon the parasite load, site of larval migration, and the host’s inflammatory response. Visceral larva migrans occurs mostly in children who are at a higher risk of infection due to exposure to the eggs in sandboxes and dirt on outdoor playgrounds. Ocular larva migrans can occur even if only a single larva reaches the eye [1].


Epidemiology


Approximately 13.9 % of the US population have antibodies to Toxocara implying that millions of people have been exposed to the organism [2]. Ocular toxocariasis accounts for 1–2 % of all uveitis in children throughout the world [3]. The organism is not specific to any region of the world or US but occurs at substantially higher rates in Asia and in areas of the US with higher levels of poverty [4]. The increased prevalence of ocular toxocariasis in Asia is generally thought to be caused by food habits and traditional dishes specific to many Asian cultures. Specifically in Korea 80.8 % of ocular toxocariasis patients reported having eaten raw cow liver [5]. The higher levels of ocular toxocariasis in poverty-ridden communities in the US are associated with animal interactions, specifically stray cats and dogs, along with a higher number of pets living in less sterile environments enabling easier transmission of toxocariasis to humans [6, 7].


Clinical Manifestations


Toxocariasis manifests as two general syndromes: systemic toxocariasis and ocular toxocariasis. Systemic toxocariasis (visceral larva migrans) is typically seen in young children and can be asymptomatic. The severity of the symptoms is dictated by the age of the patient, quantity of larva ingested, distribution of the larva in the body, and host response. The condition can be mild but may be associated with a varied range of symptoms including cough, wheezing, abdominal pain, fever, and fatigue. In more severe cases, patients can develop hepatitis, pneumonitis, and encephalitis [8]. Ocular involvement is usually not present in cases of systemic toxocariasis, and conversely systemic toxocariasis is rarely seen in cases of ocular toxocariasis.

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Aug 17, 2017 | Posted by in OPHTHALMOLOGY | Comments Off on Ocular Toxocariasis

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