73 Microbiology of ENT
73.1 Ear Infections
(See also chapters in Section I)
73.1.1 Otitis Externa
• Acute infection
This is an inflammation of the ear canal, commonly caused by bacterial infection
Symptoms can include itchiness, discharge, and pain
Common bacterial causes: Staphylococcus aureus (yellow crusted discharge), Streptococcus pyogenes are the most common pathogens
Treatment should be with ear drops if mild or systemic in severe cases
• Chronic (swimmer’s ear) infection
Ongoing mild infection—may be due to underlying seborrhoeic dermatitis or frequent swimming or diving leaving the ear canal wet
Typical pathogens are Pseudomonas species (they are water loving), S. aureus, Enterobacteriaceae, and Aspergillus species
Treatment includes aural toilet by ENT specialist and ear drops (e.g., ofloxacin 0.3% or polymyxin B + neomycin + hydrocortisone)
If S. aureus and associated pinna cellulitis, systemic treatment with antistaphylococcal agent (e.g., floxacillin) may be appropriate
• Malignant/necrotizing infection
This is a very severe form of acute otitis externa
It presents acutely with a systemic inflammatory response and fever
High-risk groups are patients with diabetes, AIDS, and those on chemotherapy; usually seen in elderly patients
The infection is mainly bacterial and includes Pseudomonas aeruginosa (90%) and S. aureus
Bony involvement is not uncommon
Ear swab and tissue should be cultured for pathogens prior to antibiotic treatment
Treatment must be initiated rapidly and includes systemic antibiotics with antipseudomonal activity, e.g., meropenem, ceftazidime, tazobactam, gentamicin, or ciprofloxacin
In osteomyelitis treatment should be for 4 to 6 weeks (CT or MRI may aid diagnosis); monitoring of inflammatory markers (e.g., C-reactive protein) can help indicate response to treatment
73.1.2 Otitis Media
• Acute infection
This is an infection of the middle ear caused by viruses and/or bacteria (S. pneumoniae, Haemophilus influenzae, occasionally Moraxella catarrhalis)
Tympanic membrane may be perforated with purulent yellow mucus and pain