Medication-associated uveitis is a rare adverse effect of drug administration that can typically induce mild to moderate intraocular inflammation. The prognosis is generally favorable as the uveitis responds well to cessation of the offending agent and use of topical and/or systemic corticosteroids. With the expanding armamentarium of available therapeutic agents, the list of drugs that can potentially induce uveitis continues to increase. At the time of this publication, multiple case series have reported uveitis associated with use of ipilimumab (a CTLA-4 inhibitor) in the treatment of metastatic melanoma [29]. The physician must be cognizant that certain medications may be associated with intraocular inflammation and have a high index of suspicion if established Naranjo criteria are fulfilled.