Medical Statistics

75 Medical Statistics


75.1 Data Display and Summary


• Categorical data—nominal (sex), grade of tumour (ordinal)


• Quantitative data—measured or counted, e.g., age, blood pressure


• Measure of variation—interquartile range and median


• Histograms—display grouped frequency (distribution of a continuous variable)—should generally have 5 to 15 groups


• Bar charts—distribution of a discrete variable or a categorical one (spaces between bars)


75.2 Summary Statistics for Quantitative and Binary Data


• Mean will be affected by outlying data, median will not


• Standard deviation (SD) gives an indication of the spread about the mean—relies on the data being symmetrically distributed


• If normal distribution occurs:


figure Mean ± 1 SD = 68% of data


figure Mean ± 2 SD = 95% of data


figure Mean ± 3 SD = 99.7% of data


• SD in ungrouped data uses degrees of freedom = division by total number of observations minus 1


• Skewed data are often best presented via a log transformation


• Measurement error—SD for repeated measurements


• Coefficient of variation = intrasubject SD/mean expressed as a percentage


• Absolute risk reduction (ARR) = difference between 2 risks for 2 treatments (%age)


• If new therapy beneficial = number needed to treat—ARR will be +ve (1/(P1 − P2))


• Risk ratio or relative risk (RR)—if <1 = lower risk in control group


• RR reduction = (control risk—experimental risk)/control risk


• Odds (event) = probability of event happening (P)/(1 − P)


• Odds ratio (OR) = odds of event 1/odds of event 2


• Use of median or mean does not depend necessarily on distribution of data; if there is a small group at one extreme of the distribution then the median will be more useful, otherwise the mean is generally preferred


• Data not normally distributed may well derive useful information from both median and mean


• SD is only interpretable for variables that have approximately symmetrical distribution


• SD should not be used for data that are not plausibly normal e.g., age—interquartile range (IQR) better


• Case-control studies—quote OR


• Cross-sectional studies—either OR or RR


75.3 Populations and Samples


• Standard error (SE) used to study significance of difference between 2 means = SD/n; measure of precision of a population parameter


• Random sampling allows a population to be studied more conveniently—may be stratified to allow for age/sex distribution


• Unbiased measurement = average of a large set will be close to the true value


• Precise measurement = repeatable


• Non-random samples, e.g., hospital patients vs. community, volunteers vs. non; reduce biases by providing demographic data


• Acceptable response rate from a survey = 65 to 70%; useful to present data on nonresponders; smaller responses valid if no biases


• Sample SD = estimate of population parameter (variability of observations)


• SE of an estimate will decrease with increasing sample size


• SD is used to describe data, i.e., normal distribution


• SE is used to describe the outcome of a study, e.g., estimate the prevalence of disease


75.4 Statements of Probability and Confidence Intervals


• 95% limits = reference range = mean ± 1.96 SD (~ 2 SD)


p-value = probability of getting the observed value (or more extreme) if the null hypothesis were correct (e.g., p < 0.05)


• 95% CI = mean ± 1.96 SE (~ 2 SE)—this indicates that only 5% chance that this range excludes the mean


• Reference range refers to individuals; confidence interval (CI) refers to estimates


75.5 Differences between Means: Type I and Type II Errors and Power


• Null hypothesis = no difference between populations compared


• Type I error = rejection of null hypothesis when in fact it is true—using mean ± 1.96 SE = 1/20 chance of being wrong


• A non-significant difference does not make the null hypothesis likely; this is just absence of evidence


• If CI excludes 0, the chance of samples being from same population is less than 5%

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Jul 4, 2016 | Posted by in OTOLARYNGOLOGY | Comments Off on Medical Statistics

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