Endophthalmitis

Chapter 14 Endophthalmitis




Infectious endophthalmitis occurs when bacteria, fungi, parasites, or viruses enter the eye following a breach of the outer wall of the eye (exogenous endophthalmitis), or when microorganisms enter the eye from a source elsewhere in the body (endogenous endophthalmitis). Exogenous endophthalmitis most frequently arises following surgery but may be a consequence of trauma. Endogenous endophthalmitis usually results from hematogenous spread of infection. Exogenous endophthalmitis may be sub-classified into acute and chronic. The classification of endophthalmitis is important as each type has a characteristic clinical setting, differing spectrum of microorganisms, and varying visual prognosis.



Clinical presentation


The presentation of bacterial endophthalmitis depends on the route of infection and the virulence of the microorganism. Acute postoperative endophthalmitis typically presents 1−3 days after surgery with pain and decreased vision. There is often lid swelling, conjunctival injection, corneal edema, and chemosis. Intraocular findings include uveitis, hypopyon, vitreous cells, and occasionally sheathing of blood vessels. In children, presentation and treatment are often delayed particularly following trauma where occult penetration may go undetected.


Infection with less virulent organisms may result in chronic or late onset endophthalmitis, which may run an indolent course with exacerbations and remissions. Intraocular inflammation is less severe, but hypopyon and vitreous activity may be present. The presence of creamy white plaques on the posterior capsule following cataract surgery is suggestive of Propionibacterium infection. In endophthalmitis following penetrating injury there may be a persistent severe uveitis and vitreous haze with infiltration of the wound edges. Retinal periphlebitis may be an early sign of bacterial endophthalmitis. Endophthalmitis should be suspected after intraocular surgery or traumatic perforation whenever the inflammation is greater than expected. Serial and frequent examinations may be necessary. The main differential diagnoses are fungal endophthalmitis and severe uveitis. Rarely, retinoblastoma or metastatic tumor may present with uveitis and hypopyon.



Exogenous bacterial endophthalmitis



Cataract surgery


Exogenous endophthalmitis in adults occurs most frequently following intraocular surgery (70−80%). Cataract extraction has a reported incidence of postoperative endophthalmitis of 0.1−0.38%1 (Fig. 14.1). Good et al. reported an incidence of 0.45% in a retrospective review of 641 cases of cataract extraction in children.2 Wheeler et al. reported an incidence of 0.07% in children undergoing cataract and glaucoma surgery.3



Endophthalmitis following cataract surgery in adults is associated with rupture of the posterior capsule. Surgery for congenital cataract, whether lensectomy or lens aspiration, usually involves breach of the posterior capsule. Therefore, one might expect a higher incidence of postoperative endophthalmitis similar to that reported in intracapsular cataract, posterior capsular tear, and anterior vitrectomy.


Toxic anterior segment syndrome (TASS) may be difficult to distinguish from infective endophthalmitis. TASS is a sterile inflammatory response usually occurring in the first 48 hours following cataract surgery. If doubt exists as to whether the patient has endophthalmitis or TASS, vitreous biopsy and intravitreal antibiotics are warranted.


The Endophthalmitis Vitrectomy Study (EVS) studied 420 cases of infectious endophthalmitis presenting within 6 weeks of cataract extraction or secondary intraocular lens implantation.4 Positive culture was obtained from 69.3% of intraocular specimens. Gram-positive bacteria were isolated in 94.2% of cases and Gram-negative bacteria in 6.5% of isolates. Staphylococcus epidermidis, normal skin flora, was by far the most common gram-positive isolate (70%), followed by Staphylococcus aureus (9.9%), Streptococcus spp. (2.2%), and Propionibacterium acnes. Proteus and Pseudomonas were the most common Gram-negative organisms. Haemophilus influenzae has also been identified in other series.5 Weinstein’s study of children with endophthalmitis reported similar results, 75% of culture positive cases being caused by Gram-positive organisms.6 Staphylococcus epidermidis, Streptococcus pneumoniae, and Staphylococcus aureus have been identified as the most frequent infecting agents in children following cataract extraction.




Glaucoma filtration surgery


Infection associated with filtration surgery is often sub-classified into blebitis, defined as mucopurulent material in and around the bleb associated with anterior segment activity but without hypopyon. If a hypopyon is present, or there is evidence of vitreous activity, a diagnosis of endophthalmitis is made. Endophthalmitis may occur soon after surgery, but is frequently reported many years after surgery. Antimetabolites such as 5-fluorouracil (5-FU) and mitomycin C are used to augment filtration surgery in childhood glaucoma. While improving the success rate of filtration surgery they increase the risk of postoperative endophthalmitis. When intraoperative 5-FU is used, the reported incidence of endophthalmitis is 1−5.7%. The incidence of endophthalmitis is 0.3−4.9% when mitomycin C is applied.10


Implantation of glaucoma drainage devices is associated with increased rates of endophthalmitis. A review of 542 eyes with Ahmed valve insertion noted an endophthalmitis rate significantly higher in children. The incidence in adults was 1.7%, compared to 4.4% in children.11 Endophthalmitis is often associated with conjunctival erosion and tube exposure; inferior placement of bleb or drainage device is also associated with higher rates of infection. When endophthalmitis is related to glaucoma surgery, the spectrum of microorganisms differs from that in cataract surgery in that streptococcal species predominate. Haemophilus influenzae is also isolated more frequently than Staphylococcus epidermidis. This difference may reflect the fact that endophthalmitis is often of late onset with invasion of microorganisms through thin walled or leaking blebs.12 Jampel et al. found increased incidence of endophthalmitis associated with full thickness filtration procedures, inferior placed blebs, bleb leakage, and the use of mitomycin.13 If endophthalmitis develops in the early postoperative period, Staphylococcus epidermidis is more frequently cultured.



Strabismus surgery


Endophthalmitis following strabismus surgery is rare, with an incidence of 1 : 3500 to 1 : 185 000.14 Scleral perforation is thought to be a prerequisite for the development of endophthalmitis following strabismus surgery. Spatulated needles have greatly reduced the frequency of scleral perforation during strabismus surgery. Needles and sutures are frequently contaminated despite the use of preoperative povidone-iodine. Carothers et al. noted 19% of needles and 24% of sutures were culture positive in patients undergoing strabismus surgery.15

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Jun 4, 2016 | Posted by in OPHTHALMOLOGY | Comments Off on Endophthalmitis
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