Fig. 4.1
(a) Traction sutures placed at 3 and 9 o’clock to avoid distortion of scleral flap. (b) Traction suture placed at 6 o’clock to avoid distortion of scleral flap
Both of these options avoid a gaping effect on the scleral flap, which can cause aqueous flow from the anterior chamber and distort the anatomy.
If the cornea is perforated full thickness, during placement of the traction suture this should be easily identified by not only sensation but also the egress of aqueous. Simply withdraw the needle and hydrate the wound if need be and place the suture more superficially elsewhere. Should the anterior chamber have gone very shallow, simply wait and it will refill allowing the operation to proceed as usual.
We recommend releasing the traction suture prior to entering the anterior chamber to avoid the risk of anterior chamber shallowing and difficulty closing the scleral flap due to countertraction (if the traction suture is in the 12 o-clock position).
Surgical Step
Conjunctival incision and dissection.
Potential complication
Incomplete dissection of Tenon’s capsule from sclera.
This can lead to difficulty in dissecting the scleral flap, as the Tenon’s tissue can make it difficult to judge the depth of the scleral flap. Releasable sutures can also become embedded in Tenon’s which is adherent to the sclera, making them prone to snapping when trying to remove them.
How to Avoid
Tenon’s attaches approximately 0.5 mm behind the anatomical limbus. While dissecting, take the decision to take both the Tenon’s and conjunctival tissue at the same time, or dissect each layer in turn. We find that a generous conjunctival opening at the limbus, enables easier and cleaner dissection of the Tenon’s from the scleral bed. Should there be any adherent Tenon’s capsule on the sclera, it is important to remove this by gentle scraping with a Tooke’s knife, or similar instrument. Alternatively gentle cautery may shrink the adherent Tenon’s for easy removal.
We find combined closure of the Tenon’s and the conjunctiva at the limbus very helpful. If the Tenon’s tissue is not brought forward at the limbus, then it can stick down posteriorly with scarring and cause the trabeculectomy to fail. Meticulous dissection at the start of the operation facilitates bilayered closure at the end.
Surgical step
Conjunctival incision and dissection.
Potential complication
Conjunctival buttonholes.
How to avoid
Our standard technique is a fornix-based conjunctival flap. After the conjunctiva and Tenon’s tissue has been dissected from the limbus, try to only grasp Tenon’s tissue, either by rolling the limbal tissue backward over your forceps and so the Tenon’s tissue is presented anteriorly, or by sliding a pair of toothed forceps underneath the Tenon’s and grasping it from the under surface. This enables you to hold the “meaty” part of the Tenon’s tissue and avoids accidental buttonhole of the conjunctiva when grasping both tissues together.
Some patients do however have very friable conjunctiva, and no matter how careful the dissection, conjunctival buttonholes may occur. Should a conjunctival button hole arise, it can be cut out if sufficiently anterior and enough tissue is available to be brought down to the limbus after the buttonhole has been excised. If the buttonhole is posterior, then we would ordinarily repair with a purse-string suture, of either 10/0 vicryl or nylon. Both these sutures have their merits. Vicryl is absorbable and due to the “vicrylitis” or tissue inflammation, encourages tissue healing. The healing, however, may be overaggressive and encourage scarring of the trabeculectomy. The nylon suture is only slowly absorbable, so may need removal at some stage. It is, however, less inflammatory for the tissues. Care must be taken to gently close the buttonhole, so as not to cheese-wire the tissue and create an extension of the original buttonhole. Completion of the suture from the undersurface of the conjunctiva ensures very good burying of the knot and fewer problems.
Surgical Step
Cytotoxic application.
Potential Complication
Thin-walled cystic bleb.
How to Avoid
We advocate, as part of the Moorfields Safe Surgery technique, that a large area of cytotoxic is applied more posteriorly (Dhingra and Khaw 2009). To achieve this, Tenon’s tissue is grasped at the limbal end of dissection, to keep it away from mitomycin C (MMC) and avoid contact of MMC with the conjunctiva. MMC soaked sponges are placed on the scleral bed, to give a large, posterior treatment area. Any excess MMC that has washed up at the limbus, is dabbed, during the 3-min treatment period. The sponges are then removed and the scleral bed is irrigated copiously with 20 ml of balanced salt solution (BSS). A large posterior treatment area is important, as it promotes diffuse posterior flow of aqueous and we believe may help prevent a “ring of steel” forming.
Surgical Step
Cautery.
Potential Complication
Focal thinning of sclera with aggressive cautery.
How to Avoid
Although cautery is important to stop bleeding from episcleral and scleral vessels, aggressive cautery can cause focal scleral thinning, and irregular thickness to the scleral flap. Most bleeds do stop of their own accord, when given time. Another trick to reduce bleeding is to use topical 0.1 % epinephrine. The vasoconstriction decreases vascularity in the operative field and aids in the cessation of bleeding.
Surgical Step
Scleral flap dissection.
Potential Complication
Thin scleral flap: Full-thickness hole in scleral flap.
How to Avoid
Thin scleral flaps are trouble. Sutures cheese-wire through them. They are difficult to close and can lead to anterior leaks and hypotony.
The key is recognition on the operating table. First, if there is an area of thin sclera, try and avoid this and move the site of the flap, laterally or medially to an area of healthier sclera.
If one does inadvertently create a full-thickness hole in the scleral flap, it can be subtle and we always recommend checking for leaks. Use of 2 % fluorescein after the flap has been sutured closed and the anterior chamber refilled to a physiological pressure with BSS via the paracentesis helps considerably in this respect. If a full-thickness hole is detected, then this should be closed with either a patch of Tenon’s (autograft), or tutoplast at the time of surgery.
If the flap is very thin overall, one can cut a flap around the original flap (see Fig. 4.2a), at a deeper depth, thus incorporating the original thin flap. This a good option, as normal anatomy is retained, it facilitates good flap closure and the position of the trabeculectomy remains optimal.
Fig. 4.2
(a) Dissection of a larger, thicker scleral flap, which incorporates the original thin scleral flap. (b) Dissection of a rotational scleral flap, which covers over the original thin scleral flap
An alternative is to move to a new site.
Finally, if the leak is persistent and material scarce, a rotational scleral flap may be fashioned and folded over the original thin scleral flap (see Fig. 4.2b).
Surgical Step
Scleral flap dissection.
Potential Complication
Thick scleral flap: Valving.
How to Avoid
Valving is the phenomenon that occurs when drainage only occurs on applying pressure behind the scleral flap. It is because there is no overlap of the side arms of the scleral flap and the sclerostomy (see Fig. 4.3a, b).
Fig. 4.3
(a) A valving effect is created due to lack of overlap between side arms of scleral flap and sclerostomy. (b) Overlap of side arms of scleral flap and sclerostomy, thus avoiding valving effect
In order to detect valving, it is important to check drainage at the time of surgery. Once the sclerostomy and peripheral iridectomy are created, the scleral flap should be folded down, but not sutured down and the anterior chamber refilled with BSS via the paracentesis. If BSS is freely flowing out of the flap and the anterior chamber is spontaneously shallowing, then valving is not present and the flap can be closed. If on the other hand, no flow is seen from the back end of the flap once the anterior chamber is filled it indicates that aqueous will not drain from the flap, even if all the sutures have been removed. If this occurs two measures can be taken. The first is to cut-down the side arms more anteriorly. This however should not be undertaken, if the side arms are already very anterior, as it can lead to postoperative limbal leaks. The alternative is to enlarge the sclerostomy posteriorly. Once, one or both of these steps have been undertaken, then fold the flap back down and test again for flow. Once, you are confident that flow is present, then the flap can be sutured down.
Surgical Step
Scleral flap dissection.
Potential Complication
Thick scleral flap: Full-thickness initial incision. Persistent hypotony.
How to Avoid
A full-thickness incision is not always spotted at the time of surgery and equally may not always lead to trouble. None-the-less it can result in persistent hypotony and the explanation only becomes clear on exploration of the operative site. A full-thickness incision most commonly occurs during the initial creation of the posterior flap edge, but full thickness can also be achieved with side arms and with enthusiastic flap dissection (both free hand and with the crescent knife). The principal method of avoidance is being aware that this can happen and lead to problems. If it does occur, suturing the defect is the simplest approach. In order to repair the defect, finish creating the scleral flap; this enables complete visualization of the full-thickness defect and avoids distortion while suturing it closed. It is important that the full-thickness incision is completely clear and then closed with either interrupted or box suture(s) (see Fig. 4.4a, b).
Fig. 4.4
(a) Creation of a full-thickness incision in sclera, when creating initial posterior scleral flap edge. (b) Repair of the full-thickness incision sutures, once scleral flap is completed
If adequate dissection is not performed then the subsequent dissection may either cut the suture out or be completely distorted by the suture. The same principal applies if undertaking a revision. Take the whole operation down and explore using 2 % fluorescein. Suture the defect and then restore normal operative anatomy in your usual fashion.
Surgical Step
Scleral flap dissection.
Potential Complication
Premature anterior chamber entry.
How to Avoid
This most usually happens at the anterior limit of sclera flap dissection. If it occurs, aqueous will be noticed at the scleral flap and the anterior chamber may shallow. A paracentesis is important for surgical control, so if there is not one already present and the anterior chamber has shallowed, insert a Rycroft cannula into the site of anterior chamber entry and fill the anterior chamber from here. Once the anterior chamber has deepened, create a paracentesis.
The site of premature entry can often be used to create the sclerostomy, it will otherwise require repair.
Surgical Step
Scleral flap dissection.
Potential Complication
Anterior drainage of aqueous, high anterior bleb with corneal epithelial disturbance.
How to Avoid
The direction of aqueous flow is related to the scleral flap shape. Aqueous will preferentially follow the shortest route from sclerostomy to subconjunctival space. Figure 4.5 illustrates how this might vary with different flap shapes and why we prefer an oblong flap.
Fig. 4.5
Preferential flow of aqueous in direction of shortest path out of scleral flap. Different flap shapes influence direction of aqueous flow
Surgical Step
Sclerostomy.
Potential Complication
Too small/too anterior: valving.
How to Avoid
See section on valving above.
Surgical Step
Sclerostomy.
Potential Complication
Too large/too posterior.
How to Avoid
When dissecting the scleral flap, correct identification of the blue-gray transition zone of the surgical limbus is key. This zone is approximately 1.2 mm and is due to the oblique interface of the sclera and cornea. Posterior to this zone is the opaque white sclera and anterior to it, is clear cornea.
When advancing from sclera to cornea, a sharply demarcated white line is encountered that roughly corresponds to the level of scleral spur. Next the tissue appears grayish over the trabeculum giving way to clear cornea at the level of Schwalbe’s line. Therefore, to ensure entry into the anterior chamber, the incision must be in the anterior portion of this transition zone (Van Buskirk 1989).
Should the sclerostomy be made too posteriorly, the danger is catching the ciliary body tissue. This can lead to profuse bleeding, or even creation of a cleft. Should this situation arise the bleeding usually stops by closing the flap, allowing blood to drain externally, and simply waiting. In the unlikely event of a cleft being created this may need suturing to close.
Surgical Step
Sclerostomy.
Potential Complication
A partial thickness/shelved sclerostomy.
How to Avoid
By definition, a sclerostomy is a full-thickness hole in the sclera. If using a scleral punch to create the sclerostomy, it is important to hold the punch vertically, to ensure a full-thickness bite of the sclera is taken. When the sclerostomy is full-thickness, a knuckle of iris tissue will often present itself, through the patent sclerostomy. If there is any doubt explore and enlarge.
Surgical Step
Surgical peripheral iridectomy.
Potential Complication
Bleeding.
How to Avoid
The iris is supplied by anterior ciliary and long posterior ciliary arteries, which anastomose at the circulus arteriosus major and then supply the substance of the iris. The iris is a vascular structure and has the potential to bleed profusely on creation of a peripheral iridectomy. In the event of hemorrhage from the iris tissue, place the scleral flap down and refill the anterior chamber via the paracentesis and wait for the bleeding to stop. The elevated anterior chamber pressure acts as a tamponade to stop bleeding. If the bleeding is profuse, another alternative is to gently press on the back of the scleral flap and allow blood to drain out via the sclerostomy. This can, however, run the risk of prolonged hypotony. Washing blood out of the anterior chamber is not for the faint-hearted and we warn against cavalier removal of blood. If it is deemed necessary, tissue plasminogen activator (tPA) can be injected into the anterior chamber enabling blood clots to be removed more freely. There is a risk of rebleeding with anterior chamber washout. This risk is increased if tPA is used.
There is a shift in paradigm regarding the creation of a surgical peripheral iridectomy. Some surgeons advocate not performing surgical peripheral iridectomy in eyes that have deep anterior chambers and are not predisposed to the iris blocking the ostium (De Barroset al. 2009). However, the risk of iris obstruction will remain should the anterior chamber shallow in the absence of a peripheral iridectomy. While this can be controlled on the operating table, care must be taken when removing releasable sutures and massaging the bleb, in an outpatient setting.
Surgical Step
Suturing of scleral flap.
Potential Complication
Perioperative hypotony.
How to Avoid
Sudden reduction in intraocular pressure and prolonged perioperative hypotony is best avoided since it may lead to suprachoroidal hemorrhage. A helpful step in prevention of prolonged hypotony is the use of preplaced scleral sutures (either releasable or fixed). These facilitate swift closure of the scleral flap and restore integrity of the eye. In eyes at higher risk of suprachoroidal hemorrhages or with advanced field loss it may be worth considering use of an anterior chamber maintainer to give greater stability of the anterior chamber.
Surgical Step
Suturing of scleral flap.
Potential Complication
Suture track leak.
How to Avoid
This commonly happens with thin scleral flaps. It can also happen with full-thickness bites through the scleral flap, particularly when taking releasables through the base of the flap (limbal end). Recognition is important, and the use of 2 % fluorescein facilitates detection of leaks. In these circumstances first consider repositioning the sutures to stop the suture track leak. If this is not practical because the scleral flap is very thin and friable or repositioning of sutures is unlikely to help, it is important to remember that they often resolve and a temporary tamponade of the anterior chamber with viscoelastic or gas may be all that is indicated. Should the flap be torn by the suture then repair may be required as outlined in the section on scleral flap dissection.