We appreciate Zhang and Hoffman’s interest and their valuable comments regarding our article. We accept that the rabbits in our study will still demonstrated an increase in weight. However, to our knowledge, the rabbits that weighed 2.5 kg are approximately 5 months of age. This means that they have reached the sexual maturity period, and therefore, their ocular structure is stable. Just like people in their twenties, although they may have variations in weight with their growth, there is less probability of changes in eyeball morphologic features. In a recent study, it was confirmed that age did not affect central corneal thickness. We also read the article published in the Journal of Cataract and Refractive Surgery that showed the changes in corneal thickness after collagen cross-linking. However, we do not agree that those results are applicable to our study, because the corneal structure of subjects in that study demonstrated ectasia, whereas the rabbits in our study had normal corneal structure. The parameter of 35 μm provided by the Zeiss Corp. is not the spot diameter on the cornea. It is the settings of the Visumax femtosecond laser device, which is the reflex beam diameter used for measurement of the contact glass thickness. In future, we will describe it in detail. Femtosecond laser-assisted cross-linking is a novel technique and further studies are needed to evaluate this procedure.
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