Preoperative Issues



Preoperative Issues


Rupal H. Trivedi

M. Edward Wilson



A thorough preoperative evaluation sets the stage for the decision making that precedes surgery.1 A comprehensive history and an ocular and systemic examination help the care team to plan the overall management of the child with a cataract. The goals of the preoperative assessment include deciding whether surgery is needed, and if needed, what the appropriate timing of the surgery is. In addition, the characteristics of the cataract are documented and the postoperative visual prognosis estimated. During the assessment, we also often gain insight into whether the child and the family will comply with the postoperative correction of residual refractive error and amblyopia treatment. These data, together, help us decide whether it is best to implant an intraocular lens (IOL) or not, and if implanted, what postoperative refractive error should be aimed for when selecting an IOL power.


IMPORTANT DECISIONS

During history taking and examination, the physician needs to make several important decisions. Among these are whether surgery is indicated or not, and if indicated, how to handle aphakic rehabilitation, etc.


Indication for Surgery

The surgeon should be careful to operate on only those cataracts where the visual disturbance is severe enough to justify sacrificing normal youthful accommodation. Indications for cataract surgery include a cataract that obstructs the examiner’s view of the fundus of the nondilated pupil or a blackened retinoscopic reflex preventing refraction of the patient. Deciding when to remove a partial cataract can be difficult. Nonverbal children add more difficulties to this decision. In each individual case, the ophthalmologist needs to use his or her best judgment about whether a partial cataract is interfering with visual functioning enough to warrant removal. Partial cataracts can be amblyogenic and may disturb emmetropization leading to abnormal axial elongation. For verbal children, cataract surgery is contemplated if Snellen visual acuity (VA) is 20/50 or worse or if the child is intolerant to glare or resistant to amblyopia therapy with documented deteriorating visual function. Since a subjective VA cannot be obtained in infants with cataracts, greater reliance is placed on the morphology of the cataract, other associated ocular findings, and the visual behavior of the child, in order to ascertain whether the cataract is visually significant or not. The degree of visual impairment induced by a lens opacity differs markedly depending on the location of the opacity. Generally, the more posterior and the more central the opacity, the more amblyogenic it is. Generally speaking, a cataract that blackens the retinoscopic reflex for 3 mm or more in the center of the pupil is considered visually significant.

If a partial cataract is being treated conservatively, it is important to carefully follow these children. Conservative treatment using mydriatic drops necessitates the patient’s wearing glasses for reading if any cycloplegic effect is induced. This has not found widespread acceptance. Associated glare and loss of accommodation are the most common obstacles. Visual outcome has also been unimpressive. Despite these limitations, the use of mydriatic drops may be kept in reserve in eyes with slowly progressive cataracts or paracentral cataracts <3 mm and, especially, in patients for whom cataract surgery needs to be deferred for any reason—be it medical (high risk for anesthesia), social, or economical.


Timing of Surgery

Deciding on the appropriate timing of surgery is most critical during early infancy. In the case of a unilateral dense cataract diagnosed at birth, the surgeon can wait until 4 to 6 weeks of age. Waiting until 30 days of age or more decreases the anesthesia-related risks and often allows term infants to be healthy enough for discharge to home after surgery. Premature babies or term infants operated before 30 days of age are usually kept overnight for observation since the incidence of apnea after anesthesia is higher. For dense unilateral cataracts documented to be visually significant at birth, waiting beyond 6 weeks may adversely affect visual outcome.2,3 In the case
of a bilateral cataract diagnosed at birth, a good visual outcome can be achieved if the child is operated before 10 weeks of age.4 The first eye surgery can be offered at 4 to 6 weeks of age, and the second eye surgery after another 1 to 2 weeks’ time. It is important to keep the time interval to a minimum between the two eye surgeries. Some surgeons advise patching the first operated eye until the second has had surgery, to prevent amblyopia in the second operated eye.5 This type of occlusion is not commonly done but undue delays between surgeries should be avoided in infants. For older children, the timing of surgery is not as crucial. In children beyond the amblyopic age, surgery can often be decided based on convenience and other logistical issues.

Sequential cataract surgery, more popularly known as immediately sequential bilateral cataract surgery (ISBCS), remains controversial (see Chapter 9). Almost every discussion on ISBCS either starts or ends with a comment on the disagreement surrounding its use. The important question is not “can it be done?” but, more properly, “should it be done?” Even conservative surgeons, who vote against the routine use of ISBCS in children, are more likely to use this approach when anesthesia poses more than average risks or if the patient lives far away and a visit for surgery on the second eye would be difficult.

Timing of surgery in children with traumatic cataract, uveitis, and retinoblastoma is discussed in appropriate chapters (see Chapters 35, 38, and 40).


Aphakic Rehabilitation

IOL implantation in children has the benefit of reducing dependency on compliance with other external optical devices (aphakic glasses and contact lenses) and providing at least a partial optical correction constantly. These are important advantages to the visual development in amblyopia-prone eyes. However, concerns about primary IOL implantation are the technical difficulties of implanting an IOL in the eyes of small children, selecting an appropriate IOL power, and the risk of visual axis opacification (VAO) after implantation in the very young.6 On the other hand, although it is possible for an eye with a unilateral infantile cataract to achieve a good visual outcome following contact lens correction, it requires cooperation from children. Both IOLs and aphakic contact lenses may support similar VA after surgery for unilateral cataract in the presence of good compliance with contact lens. However, IOLs support better VA when compliance with contact lens wear is moderate or poor.7 For bilateral cataracts, aphakic glasses or contact lens use are reasonable options. Infant aphakia treatment study6 concluded that until longer-term follow-up data are available, caution should be exercised when performing primary IOL implantation in children aged 7 months or younger given the higher incidence of adverse events and the absence of short-term visual outcome compared with the contact lens use. For children beyond infancy, IOL implantation is less controversial and more commonly employed.






EXTERNAL EXAMINATION, ANTERIOR SEGMENT EVALUATION, AND OTHER INVESTIGATIONS

External examination of the eye with a suspected cataract usually consists of a penlight evaluation of eyelids, eyelashes, conjunctiva, sclera, cornea, and iris. Evidence of blepharitis (Fig. 5.5) or any discharge or tearing should be evaluated and if applicable, treatment should be advised prior to the proposed surgery date. For pupil—size, shape, symmetry, and reaction to light should be noted. Microphthalmia and poorly dilating pupils are indicators of arrested development and increase the risk of a poor anatomical and functional outcome after cataract surgery. It has been our impression that poorly dilating pupils indicate an overall immaturity of the anterior segment and may be a marker for increased risk of glaucoma after cataract surgery.







Figure 5.5. Blepharitis in a 6-year-old child scheduled for intraocular surgery.

After dilation, a slit-lamp evaluation should be carried out if the child is old enough to be cooperative. The slitlamp examination findings can help with the search for a cause of the cataract, help establish a prognosis, and help plan the surgical strategy. The morphology of the cataract may affect prognosis and give a clue to the etiology. Unilateral PSC should prompt a careful search for evidence of trauma. Bilateral PSC cataract may result from chronic uveitis, prolonged corticosteroid treatment for chronic disease, radiation treatment for malignancy, or nonaccidental injury (child abuse). Children with juvenile idiopathic arthritis (JIA) may have associated band-shaped keratopathy and posterior synechia. Lens subluxation, iridodonesis, and aniridia should be looked for. Total cataract involving the whole lens can occur in Down syndrome, type 1 diabetes mellitus, congenital rubella, and posterior lentiglobus. In cases of unilateral cataract, examination of the fellow eye after pupil dilation is essential to rule out asymmetric bilateral findings. Anterior lenticonus is most often associated with Alport syndrome and should be investigated accordingly. A sudden onset of total cataract may be an indication of unsuspected trauma, diabetic cataract, or preexisting ruptured anterior (reported in anterior lenticonus) or posterior capsule (reported in posterior lentiglobus). If the anterior vitreous can be visualized, the “fish-tail” sign suggests that the posterior capsule is incompetent or grossly ruptured. Fish-tail refers to the to-and-fro movement of the lens material in the vitreous as the eye gazes slightly right and left.

For children above about 5 to 6 years of age, the ability of the child to cooperate for slit-lamp examination is also an indirect indicator that the child will cooperate for Nd-YAG laser capsulotomy if needed. In children above 5 to 6 years of age with an intact posterior capsule and an AcrySof® IOL implantation, visually significant posterior capsule opacification (PCO) is known to develop most commonly at 18 to 24 months after surgery. If a child in this age range seems to be cooperative for slit-lamp examination during the preoperative evaluation, the surgeon may decide to leave behind an intact posterior capsule (assuming high odds of getting the child’s cooperation for YAG-laser if needed).

A slit-lamp examination of both parents, if possible, helps to establish the presence of familial cataracts and cataract-associated conditions. These findings can be subtle and the parents may not have been told that they have any pathology at all. Variability of the severity of cataracts within the same family is common.

OCT can be performed preoperatively if the lens is clear enough and the child is able to cooperate (see Chapter 21). Baseline specular microscopy is advised by some; however, it is more commonly used for secondary IOL implantation or anterior chamber IOL implantation.


Axial Length Measurement and Keratometry

For older children, axial length (AL) measurement can be obtained in office using ultrasound or optical biometry. This is especially important if A-scan instrument is not available in the operating room. Similarly, keratometry can be performed in the clinic.


Ultrasound Biometry

The ultrasound probe is placed into the solution and positioned parallel to the axis of the eye. Axiality is judged by watching for the correct spike patterns on the oscilloscope screen as the probe position is adjusted. The examiner should be familiar with the characteristics of a good A-scan tracing with a spike from each layer of the eye. When the probe is aligned with the optical axis of the eye and the ultrasound beam is perpendicular to the retina, the retinal spike is displayed as a straight, steeply rising echo spike. When the probe is not properly aligned with the optical axis of the eye, the ultrasound beam is not perpendicular to the retinal surface and the retinal spike is displayed as a jagged, slow-rising echo spike. Repeated measurements are taken until a few equal measurements are obtained with sharp retinal spikes.

Ultrasound can be done with either contact or immersion methods. In the contact method, the probe touches the cornea and may result in corneal compression and a shorter AL. Corneal compression is more likely in pediatric eyes because of low corneal and sclera rigidity. Using the immersion technique, the ultrasound probe does not come into direct contact with the cornea, but instead uses a coupling fluid between the cornea and probe preventing corneal indentation. Immersion A-scan has been shown to be superior to contact biometry in children.11,12 If contact A-scan is used, it is important to make sure that the tip does not indent the cornea. Pediatric cataract surgeons use the contact technique more frequently when measuring the AL of pediatric eyes at the time of cataract surgery. This statement is based on 2009 e-mail survey sent to pediatric ophthalmologists, in which 173 (82.4%) surgeons reported using contact A-scan compared with
37 (17.6%) who reported using the immersion technique.12 Because of a lack of cooperation in the clinic setting, AL measurements in young children often must be obtained in the operating room under general anesthesia. In the operating room setting, an experienced ultrasonographer may not be available. Contact A-scan measurements are easier for the surgeon or an operating room technician to perform. Immersion A-scan requires more experience and practice and is best performed by an experienced ultrasonographer. In a prospective clinical trial, we compared AL measurements by contact and immersion techniques in pediatric cataractous eyes (n = 50 eyes of 50 children).12 AL was measured by both contact and immersion techniques for all eyes, randomized as to which to perform first to avoid measurement bias. AL measurement by contact technique was significantly shorter as compared with immersion technique (21.36 ± 3.04 mm and 21.63 ± 3.09 mm, respectively; P < 0.001). AL measurements using the contact technique were on an average 0.27 mm shorter than those obtained using the immersion technique. Forty-two eyes (84%) had shorter AL when measured using the contact technique as compared with the immersion technique. Lens thickness (LT) measurements by contact technique was not significantly different from that of immersion technique (3.61 ± 0.74 and 3.60 ± 0.67 mm, respectively; P = 0.673). Anterior chamber depth (ACD) measurements were significantly more shallow with the contact technique (3.39 ± 0.59 mm and 3.69 ± 0.54 mm, respectively; P < 0.001). As can be seen here, shorter AL in contact group was mainly as a result of ACD value rather than LT value. IOL power needed for emmetropia was significantly different (28.68 diopters [D] versus 27.63 D; P < 0.001). During IOL power calculation, if AL measured by contact technique is used, it will result in the use of an average 1-D stronger IOL power than is actually required. This can lead to induced myopia in the postoperative refraction. A consistent error could be compensated for by the addition of a constant or by formula personalization; however, this is not possible because the compression error varies from eye to eye.

In a subsequent study, we compared prediction error (PE) and absolute prediction error (APE) using contact and immersion techniques.11 The contact and immersion A-scan biometry techniques had been performed in each eye and PE using each technique was compared. There was a significant difference in PE between contact and immersion A-scan biometry in children. The mean PE was +0.4 ± 0.7 D in the contact group and −0.4 ± 0.8 D in the immersion group (P < 0.001) and the mean APE was 0.7 ± 0.4 D and 0.7 ± 0.6 D, respectively (P = 0.694). The APE was <0.5 D in 5 eyes (23%) using the contact technique and in 11 eyes (50%) using the immersion technique. The mean postoperative spherical equivalent was +2.9 ± 2.5 D, which was significantly different from the mean predicted refraction for contact A-scan (3.3 ± 2.8 D; P = 0.010) but not immersion A-scan (2.5 ± 2.5 D; P = 0.065). Ben-Zion et al.13 compared PEs of 138 pediatric eyes measured by the contact A-scan technique with a later group of 65 children measured with the immersion technique. They found no significant difference in APE (1.11 and 1.03 D, respectively) and noted PE of +0.23 and −0.32 D with the contact technique and immersion technique, respectively.


Optical Biometry

Optical biometry is based on partial coherence interferometry (PCI)—IOLMaster (Carl Zeiss Meditec) or LenStar (Haag Strait). LenStar allows higher resolution compared with the IOLMaster. The measurement includes corneal thickness, ACD, LT, AL, keratometry, white-to-white distance, pupillometry, eccentricity of the visual axis, and retinal thickness at the point of fixation. It can also be used to access the horizontal iris width, pupil diameter, eccentricity of the visual axis, and retinal thickness. PCI has been used in cooperative children with reliability and accuracy. PCI requires patient cooperation and thus may not be a viable option in infants and young children. Claimed improvements over conventional ultrasound techniques include high reproducibility, contact-free measurements, and observer independence of the measurements. Lenhart et al.14 reported PE for AL measurements obtained using PCI versus immersion ultrasonography in children. AL measurements in the operative eye were obtained using PCI at the preoperative clinic visit and then using immersion US in the operating room before surgery. The data were compared to determine the degree of agreement. The charts of 18 patients (27 eyes) were reviewed. Preoperative AL measurements by PCI were obtained in 21 eyes (78%). On average, the PCI-measured ALs were 0.1 mm less than the immersion US values (95% confidence interval, −0.2 to −0.1; P = 0.002). All eyes with an AL of 23.5 mm or less had lower PCI values than immersion US values. There was no systematic pattern of 1 measurement being greater or lesser than the other in eyes with an AL longer than 23.5 mm. The authors concluded that there was a systematic difference in AL measurement between PCI and immersion technique, with PCI tending to give lower values, particularly in eyes with an AL of 23.5 mm or less. Gursoy et al.15 compared AL, ACD, and LT measured with LenStar with those obtained with A-scan contact technique. Right eyes of 565 school children were included (mean age 10.5 years). The mean difference between contact ultrasound and LenStar was −0.72, −0.27, and +0.24 mm for AL, ACD, and LT, respectively. PCI technology is not able to obtain measurements in eyes with dense cataract and in those that cannot fixate on the red light of the instrument because of inadequate vision. In children, the cataracts are often dense and fixation may be inadequate.



Biometry Values in Eyes with Pediatric Cataract

We reported biometry data of pediatric cataractous eyes (randomly selected single eye in bilateral cases; cataractous eye in unilateral cases).16 Three hundred ten eyes were analyzed, with a mean age at cataract surgery of 45.30 ± 48.1 months (median, 27.50; range, 0.23-203.08); mean AL of 20.52 ± 2.87 mm (range, 14.19-29.10); ACD of 3.29 ± 0.60 mm (range, 1.48-4.35); and LT of 3.62 ± 0.86 mm (range, 0.61-6.35). Table 5.1 shows the mean AL per age group. In Table 5.2, the first 2 years of life are divided into age groups, showing the mean AL per age group.

The overall mean AL of pediatric cataractous eyes (20.5 ± 2.9 mm) in our series was significantly different (P < 0.001) than the overall mean AL of pediatric non-cataractous eyes described in a Gordon and Donzis series (21.9 ± 1.6 mm).17 More important, the standard deviation was nearly two times more in eyes with cataract than in those without (±2.9 mm versus ±1.6 mm). This difference is a very important factor to keep in mind; that is, these cataractous eyes are abnormal to begin with, which may also lead to variations in postoperative growth. Eyes with cataract showed a shorter AL in the first 12 months of life (cataractous, 17.9 ± 2.0 mm; noncataractous, 19.2 ± 0.7 mm). In the first 12 months of life, the standard deviation was almost three times that of eyes without cataract (±2.0 mm versus ±0.7 mm).








Table 5.1 AL MEASUREMENTS IN UNILATERAL AND RANDOMLY SELECTED SINGLE EYES OF PEDIATRIC PATIENTS WITH BILATERAL CATARACTS, CATEGORIZED BY AGE























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May 24, 2016 | Posted by in OPHTHALMOLOGY | Comments Off on Preoperative Issues

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Agea (y)


n


Length (Mean ± SD)


95% CI


Range


<1


119


17.67 ± 1.88


17.33-18.02


14.19-22.62


1-2


30


21.54 ± 1.34


21.04-22.04


19.09-25.86


2-3


19