Immunology of Allergic Disease

the type IV (late-phase) symptoms of chronic nasal congestion 24 to 48 hours after allergen exposure.


• Some watery discharge is also produced by the late-phase allergic response.


Priming Effect


• The allergen dose needed to elicit a response decreases with multiple exposures to that allergen.


• This means patients will often start to experience symptoms very early in the pollen season when levels are still low.


• Over the season more inflammatory cells migrate to the submucosa.


• Sensory nerves are stimulated by inflammatory cell products to lower their threshold for activation.


• Eosinophil-derived nerve growth factor increases sensory nerve expression of transient receptor potential vanilloid 1 receptor; this is the receptor through which histamine largely works through to induce neural symptoms.


• Towards the end of the pollen season, a lower level of allergen will cause more symptoms in the presence of activated sensory nerves and more submucosal inflammatory cells.


• Patients will also still experience significant symptoms towards the end of the season when pollen levels are dropping.

Only gold members can continue reading. Log In or Register to continue

Jul 20, 2019 | Posted by in OTOLARYNGOLOGY | Comments Off on Immunology of Allergic Disease
Premium Wordpress Themes by UFO Themes