High Accommodative Convergence to Accommodation Conditions: Convergence Excess and Divergence Excess



High Accommodative Convergence to Accommodation Conditions: Convergence Excess and Divergence Excess





This chapter discusses the characteristics, diagnosis, and management of nonstrabismic binocular disorders associated with a high accommodative convergence to accommodation (AC/A) ratio. As described previously, the AC/A ratio is the major factor that determines the sequence of management decisions in patients with heterophoria (Chapter 3). Consequently, certain general treatment strategies are shared by all binocular conditions associated with a high AC/A ratio. However, there are also important differences among patients with high AC/A ratios who have convergence excess and those who have divergence excess. After a review of the general principles that apply to all high AC/A disorders, each condition is described separately to highlight the differences in characteristics, diagnosis, and management.

The specific conditions that are discussed in this chapter are the various forms of convergence excess and divergence excess.


Overview of General Management Principles for Heterophoria Associated with High AC/A Ratio

For binocular vision disorders associated with a high AC/A ratio, the specific management sequences are listed in Tables 10.1 and 10.2. The major difference that distinguishes high AC/A problems from conditions associated with low and normal AC/A ratios is the relative effectiveness of added lenses in effecting a change in the size of the heterophoria. An example of this is the patient with convergence excess described in Case 10.1.










Table 10.1 SEQUENTIAL CONSIDERATIONS IN THE MANAGEMENT OF CONVERGENCE EXCESS

















Optical correction of ametropia


Vision therapy for amblyopia


Added lens power


Vision therapy for suppression


Vertical prism


Vision therapy for sensory motor function


Horizontal prism


Surgery


Occlusion for amblyopia









Table 10.2 SEQUENTIAL CONSIDERATIONS IN THE MANAGEMENT OF DIVERGENCE EXCESS


















Optical correction of ametropia


Vision therapy for suppression


Vertical prism


Vision therapy for sensory motor function


Added minus lens power


Horizontal prism


Occlusion for amblyopia


Surgery


Vision therapy for amblyopia



Another example of the effectiveness of added lenses in high AC/A cases is illustrated in Case 10.2.


Optical correction of ametropia still remains the first issue that should be considered. However, as evidenced by Case 10.2, the consideration of added lenses is close to the top of the list in Table 10.1. In high AC/A cases, correction of the refractive error may be helpful for two reasons. The first is that the presence of an uncorrected refractive error may create an imbalance between the two eyes, leading to sensory fusion disturbances, or may create decreased fusional ability because of blurred retinal images. The second reason is that, because of the high AC/A, correction of the ametropia may have a beneficial effect on the magnitude of the deviation.

When considering the final prescription for these patients, it is important to first determine whether a vertical deviation is present. As discussed in previous chapters, correction of even small amounts of vertical deviations can have a positive effect on the horizontal deviation. We suggest prescribing for vertical deviations as small as 0.5 Δ (Chapter 14).

A key difference between the sequential management of convergence excess and divergence excess is that esophores are more likely to benefit from horizontal prism than exophores. The use of base-out prism is an early management consideration in convergence excess, but the use of base-in is near the bottom of the list for divergence excess (Tables 10.1 and 10.2). Because of the effectiveness of added lenses, prism is rarely necessary for convergence excess associated with normal tonic vergence (orthophoria at distance). An example of the value of base-out prism in the treatment of convergence excess, however, is illustrated in Case 10.3.



Thus, in cases of convergence excess associated with high tonic vergence, horizontal prism is an important consideration. When convergence excess is associated with a normal or low tonic vergence, prism is generally not necessary.

Although amblyopia is uncommon in nonstrabismic binocular vision anomalies, it can occur if the phoria is associated with a significant degree of anisometropia. Although anisometropic amblyopia is typically shallow (about 20/60 to 20/80), one of the early considerations should be treatment of amblyopia using occlusion and vision therapy. The use of occlusion and specific vision therapy procedures for the treatment of the amblyopia, and any associated suppression, always needs to be considered immediately after prescribing for the anisometropia and considering prism to compensate for a vertical phoria. In cases of convergence excess or divergence excess associated with anisometropia, we recommend part-time occlusion. Several (2 to 4) hours of occlusion using an opaque patch along with active amblyopia therapy is usually sufficient to resolve the amblyopia. Details regarding the evaluation and management of anisometropic amblyopia are provided in Chapter 17. In almost all cases, however, amblyopia will not be present in either convergence or divergence excess. Thus, after consideration of ametropia, added lenses, and prism, vision therapy is the next treatment issue.

In many cases of convergence excess, the use of added lenses and prism will be sufficient to successfully treat the patient. If NFV is severely reduced, or the magnitude of the esophoria is very large, or if the patient remains uncomfortable even after wearing the glasses, vision therapy should be recommended. In contrast, vision therapy is the primary treatment option for divergence excess. In general, vision therapy is more effective for divergence excess, whereas base-out prism and added plus lenses tend to be more effective for convergence excess.

The final sequential management consideration listed in Tables 10.1 and 10.2 is surgery. Convergence excess can almost always be successfully managed with a combination of nonsurgical methods. Divergence excess may at times present with a very large-magnitude exotropia at distance. When the size of the deviation is greater than 30 to 35 Δ, surgery is sometimes necessary to supplement other nonsurgical approaches.


PROGNOSIS FOR BINOCULAR VISION DISORDERS ASSOCIATED WITH HIGH AC/A RATIOS

The prognosis for successful treatment of convergence excess is excellent. In many cases the use of lenses, added lenses, and prism will be sufficient. If the patient is still symptomatic after these other interventions, vision therapy can be used and will generally lead to success. It would be rare, therefore, to be unable to successfully treat a patient with convergence excess. Failures with these patients are almost always associated with refusal to wear glasses or poor compliance with vision therapy.

The treatment of convergence excess with vision therapy has received some attention in the literature. In a record review of 12 patients with convergence excess who underwent vision therapy, Shorter and Hatch1 found that
8 (66%) of 12 patients reported improved symptoms, and 5 (62.5%) of the 8 patients with complete data showed increased NFV. The changes were not statistically significant, however. Grisham et al2 and Wick3 each reported a case of convergence excess that showed increased NFV and reduced symptoms after vision therapy. Ficcara et al4 performed a retrospective review of 31 patients (mean age 15.9 years) with convergence excess. The mean number of vision therapy visits was 19.4. There was a significant reduction in symptoms and significant improvement in NFV and PRA. The authors found that the most important factor in determining success was the magnitude of the near phoria prior to vision therapy. Gallaway and Scheiman5 also performed a retrospective analysis of 83 consecutive patients treated with vision therapy for convergence excess. In contrast to the study by Ficcara et al,4 which took place at an optometry school clinic, this study consisted of private practice patients. Thus, the testing was standardized within a practice, and two clinicians performed all the measurements. Statistically significant changes were found in direct and indirect measures of NFV, and 84% of patients reported total elimination of symptoms. Vision therapy does appear to be a viable alternative for patients with convergence excess.

In contrast to the success of added lenses with convergence excess, divergence excess responds best to vision therapy. Many studies have evaluated the efficacy of vision therapy for divergence excess. Goldrich6 reported on the success of vision therapy in a sample of 28 divergence excess patients. He developed criteria for excellent, good, fair, and poor outcomes. To be placed in the excellent category, a patient had to be free from asthenopia, have a phoria at all times, and have normal binocular findings. Placement in the good category meant that the patient was also free from asthenopia and had a phoria at all times, but could have deficiencies on some binocular test findings. A fair result meant that an intermittent strabismus was occasionally observed on cover testing, and a poor result suggested that little improvement had occurred. Twenty patients (71.4%) achieved an excellent rating, and three patients (10.7%) had a good rating. Thus, in 82.1% of the patients, vision therapy was successful in eliminating the intermittent strabismus and asthenopia. For the subjects in the excellent category, the mean number of therapy visits was 20.2 sessions, and for the good category, 28.3 sessions. Only 1 patient was rated poor after treatment.

Pickwell7 reported on the results of vision therapy on 14 divergence excess patients; 10 patients achieved a satisfactory level, 2 patients showed measurable improvement, and 2 others discontinued therapy before completion. Daum8 did a retrospective study of 18 divergence excess patients. The duration of treatment was unusually short, only 5.2 weeks, which raises questions about the meaning of his treatment results. However, he did suggest several interesting points relative to prognosis. He found that success was significantly better in subjects who had lower angles of deviation and no vertical deviation.

Other authors who have studied the effectiveness of vision therapy for intermittent exotropia did not differentiate divergence excess from other types of intermittent exotropia. Although this makes the results more difficult to analyze, the results still have relevance for understanding the effectiveness of vision therapy for divergence excess. Divergence excess is the most common type of intermittent exotropia for which surgery is likely to be recommended. As a result, it is reasonable to suggest that many of the patients reported in the following studies had divergence excess strabismus.

In a study of 37 exotropes, Sanfilippo and Clahane9 found an excellent result in 64.5%, a good result in 9.7%, and a fair result in 22.6%. Only 1 patient (or 3.2%) had a poor result. The authors considered 64.5% to be “cured,” and 32.3% to have immediate improvement in status. They also provided useful data about various factors that influenced the effectiveness of treatment. Amblyopia, a constant deviation, noncomitancy, and a vertical component were negative factors.

Cooper and Leyman10 reported on a retrospective study of 182 intermittent exotropes treated with orthoptics alone. They found a good result in 58.7% and a fair result in 38.4%. Only 5.6% of their sample failed to make significant progress with orthoptics. Coffey et al11 reviewed 59 studies of intermittent exotropia treatment and compiled pooled success rates. They calculated the following pooled success rates: 28% for over minus therapy, 28% for prism therapy, 37% for occlusion, 46% for surgery, and 59% for vision therapy. Cooper and Medow12 also reviewed the literature and concluded that divergence excess in patients younger than 6 years should be treated cautiously so as to reduce or eliminate the possibility of developing amblyopia or permanent loss of stereopsis. They suggested various nonsurgical intervention approaches such as patching, minus lens therapy, and home-based antisuppression treatment initially. Only if the deviation persists or increases should surgical intervention be considered. They suggested that in children older than 6 years, vision therapy is the treatment of choice unless the deviation is large (>35 Δ).

In a recent prospective study by Ma et al,13 the authors evaluated changes in the Office Control Score after office-based vergence/accommodative therapy for intermittent exotropia in children 12 to 17 years old. They enrolled 14 Chinese participants, ages 6 to 17 years, with intermittent exotropia (excluding the convergence insufficiency type). All participants were treated with 12 weeks of office-based vergence/accommodative therapy. Therapy included vergence, accommodative, antisuppression, and monocular fixation in binocular field techniques. The primary outcome measure was the change in the Office Control Score from the baseline visit to the
13-week outcome visit. In this selected group of children with intermittent exotropia, 12 weeks of office-based vergence/accommodative therapy with home reinforcement resulted in statistically and clinically meaningful improvement in distance control of the exodeviation.

Thus, although the current literature lacks a high-quality randomized clinical trial, it does support the effectiveness of vision therapy in the treatment of divergence excess and, when compared to the cure rates for surgery described later in this chapter, suggests that vision therapy should be the first treatment option. It is important to keep in mind some of the negative prognostic factors suggested by the studies described earlier. Negative factors include a large angle of deviation (>35 Δ), a large vertical component, and a noncomitancy.


SUMMARY OF KEY POINTS IN TREATING PHORIA PATIENTS ASSOCIATED WITH HIGH AC/A

The primary determinant of the management sequence of high AC/A binocular vision problems is the effectiveness of added lenses. Because of the high AC/A ratio, added lenses have a significant effect on the angle of deviation and are, therefore, an important early treatment consideration. When esophoria is present at distance and correction of hyperopia is not sufficient to decrease the phoria to a manageable level, base-out prism is sometimes useful. At times, the use of lenses, added lenses, and prism will not be enough to restore comfort, and vision therapy is necessary.


Convergence Excess

Convergence excess is a condition in which there is an esophoria at near, orthophoria or low to moderate esophoria at distance, reduced NFV, and a high AC/A ratio. Of the various nonstrabismic binocular vision problems seen in clinical practice, convergence excess is one of the most common. Hokoda14 found a prevalence rate of 5.9% in a population of symptomatic individuals seeking vision care. In contrast, 4.2% were found to have convergence insufficiency. Scheiman et al15 also found a higher prevalence of convergence excess than convergence insufficiency. They performed a prospective study on 1,650 children between the ages of 6 and 18 years and found a prevalence of 8.2%. In a university population, Porcar and Martinez-Palomera16 found a 1.5% prevalence of convergence excess.


CHARACTERISTICS



Signs

Signs of convergence excess are listed in Table 10.3.


Refractive Error

Convergence excess may be associated with hyperopia. This is a desirable characteristic. Because of the high AC/A ratio, correction of the hyperopia will lead to a decrease in the magnitude of the esophoria at near and at distance. As we stated earlier, one of the primary reasons for a lack of success in the treatment of convergence excess is the patient’s refusal to wear glasses. Although this is very rare, there is another treatment alternative that can be considered in such cases.

When all efforts to have the patient wear eyeglasses or contact lenses fail, pharmacologic treatment is a last resort that can be attempted. Because of the side effects and complications associated with these drugs, this approach should only be used when the patient is either very symptomatic or the deviation is intermittent and the proportion of time the eye deviates is significant and is increasing. Pharmacologic treatment involves the use of echothiophate iodide (Phospholine Iodide) drops or diisopropyl fluorophosphate ointment (DFP). Both are anticholinesterase agents that cause miosis and ciliary spasm. This reduces or eliminates the need for accommodative effort and thereby leads to less accommodative convergence and reduced esophoria.

Echothiophate iodide solution comes in concentrations of 0.03%, 0.06%, 0.125%, and 0.25%. We recommend using 0.03% echothiophate iodide solution once a day (at night) for 1 week. The use of Tylenol for the first week helps reduce the headaches associated with the ciliary spasm, which occur initially. After the first week, increase the concentration to 0.06%, and reevaluate the patient’s status in 2 weeks. Side effects and complications associated with the use of echothiophate iodide include headaches, reversible iris cysts, cataracts, and a greater risk of retinal detachment. Concurrent use of 2.5% phenylephrine has been shown to minimize the formation of iris cysts.

DEP ointment is also an anticholinesterase that can be used to treat convergence excess. A 0.25-in. strip of 0.025% ointment is applied every night. Tylenol should be used the first week or two to reduce the headaches associated with ciliary spasm. Side effects are similar to those described for echothiophate iodide.

When either drug is used, monthly reevaluations should be scheduled to monitor the patient for any side effects or complications and to assess the effect of the treatment. If symptoms have decreased or the proportion of time the deviation occurs is significantly reduced, the treatment can be continued with monthly reevaluation.


Characteristics of the Deviation

Patients with convergence excess generally have greater esophoria at near, a high AC/A ratio, and decreased NFV.

Some authors have suggested that a 10 Δ difference from one distance to another is a useful guideline. Rather than depend on this guideline, we find it more useful to think about the difference one would expect based on the presence of a high AC/A ratio. Because an AC/A ratio of greater than 7:1 is considered high, as little as a 3 Δ difference between distance and near would be sufficient to fit the diagnosis of convergence excess.

Clinicians should use their judgment and generally rely on the other characteristics, in addition to the magnitude of the angle at distance and at near, to reach a diagnosis. For instance, the near deviation may be an intermittent or constant strabismus versus a phoria at distance. This finding would also suggest a diagnosis of convergence excess. Thus, a comparison of the proportion of time the deviation is present, as well as the magnitude at distance and at near, is an important part of the diagnostic process.


AC/A Ratio

A high AC/A ratio (=7:1) is always present in convergence excess. This is well accepted, based on the calculated AC/A, and is an important factor when treatment is considered.


ANALYSIS OF BINOCULAR AND ACCOMMODATIVE DATA

All direct tests of NFV tend to be low in convergence excess (Table 10.3). This includes step, smooth, and jump vergences. In addition, all tests that indirectly assess NFV (Table 10.3) will be low as well. Tests performed binocularly with minus lenses evaluate the patient’s ability to stimulate accommodation and control binocular alignment using NFV. Two examples are PRA and BAF testing with minus lenses. A characteristic finding in convergence excess is a report of diplopia, rather than blur, as the endpoint on PRA and BAF testing. In fact,
it is important to specifically ask about diplopia when performing these tests on a patient suspected of having convergence excess.

A low finding on either PRA or BAF testing may be due to an inability to stimulate accommodation or to reduce NFV. The differential diagnosis is based on assessment of accommodation under monocular conditions. An easy and helpful technique is to simply cover one eye after the patient reports blur on the PRA test. If the blur continues, the problem is usually accommodative (accommodative insufficiency or ill-sustained accommodation). If the patient’s vision clears, the problem is associated with binocular vision (NFV). Normal monocular accommodative ability on other tests suggests reduced NFV.

Another important indirect test of NFV is MEM retinoscopy. It is not unusual to find an abnormal result on this test in convergence excess. An MEM finding of greater plus than expected suggests that the patient is using as little accommodation as possible to decrease the use of accommodative convergence. This reduces the amount of esophoria and the demand on NFV.

In some instances of convergence excess, a low-to-moderate degree of esophoria is present at distance as well. This is due to a moderate to high degree of tonic vergence. In such cases, in addition to the low NFV at near, the distance findings will be low as well.


Apr 13, 2020 | Posted by in OPHTHALMOLOGY | Comments Off on High Accommodative Convergence to Accommodation Conditions: Convergence Excess and Divergence Excess

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