Baseline Predictors of Visual Outcome


Baseline characteristic

# Patients

Summary statisticsa

Characteristics of treated eye

Type of cataract (mild/possibly developmental)

114

14 (12 %)

Orthotropic (yes)

108

80 (74 %)

Corneal diameter (mm)

114

10.5 ± 0.7, 9.0–12.5

Average central keratometric power (D)

114

46.4 ± 2.7, 40.1–53.8

Axial length (mm)

101

18.0 ± 1.3, 15.6–21.9

Intraocular pressure (mmHg)

114

12.2 ± 4.9, 3.0–24.0

Pupil diameter (mm)

101

3.3 ± 1.0, 1.0–6.0

Aphakia treatment (IOL)

114

57 (50 %)

Physiological characteristics of infant

Patient age at surgery (months)

114

1.8 (1.2–3.2), 0.9–6.8

Patient age strata at surgery (49–210 days)

114

64 (56 %)

Gestational age at birth (weeks)

102

38.8 ± 1.3, 36–42

Birth weight (grams)

112

3457 ± 489, 2041–5087

Gender (female)

114

60 (53 %)

Race (white)

114

97 (85 %)

Hispanic (yes)

114

19 (17 %)

Sociological characteristics of family

Private insurance (yes)

114

70 (61 %)b

Primary caregiver age at surgery (years)

111

29.2 ± 5.7, 16.8–41.7

Highest education level of mother or father

 High school graduate or less

111

24 (22 %)

 Vocational/some college

40 (36 %)

 College graduate

27 (24 %)

 Graduate or professional school

20 (18 %)


aThe values for the summary statistics follow one of the following forms: n (%); mean ± standard deviation, range; median (inter-quartile range), range

bThe 44 patients without private insurance reported the following insurance coverage: medicaid: 38; self-pay: 2; other: 4



Many of the characteristics of the treated eye were restricted by the inclusion and exclusion criteria for the IATS. Thus patients with a corneal diameter <9 mm or an intraocular pressure ≥25 mmHg were automatically excluded. Additionally, patients whose cataractous eye had persistent fetal vasculature (PFV) causing stretching of the ciliary processes or tractional detachment of the retina were not eligible. The presence of active uveitis or signs of previous episodes of uveitis, as well as retinal disease or optic nerve disease, that could limit the visual potential of the eye were also exclusion criteria. These are all likely poor prognostic factors, but will not be discussed in this chapter.

We used the 4.5 year recognition visual acuity (VA) data to explore the relationship between baseline variables and later visual outcome. Correlations were determined between each baseline characteristic as a single variable and logMAR VA. The results are shown in Tables 5.2 and 5.3, with statistical analyses from continuous baseline variables listed in Table 5.2 and analyses from categorical variables listed in Table 5.3. We found that only age at the time of surgery and type of health care insurance had any statistically significant relationship with logMAR VA in our sample. Nonetheless, we will initially discuss information obtained about the type of cataract.


Table 5.2
Bivariate associations of continuous baseline characteristics and visual acuity at 4.5 years of age






















































Baseline characteristic

# Patients

Spearman rank correlation coefficient for factor and visual acuity (p-value)

Characteristics of treated eye

Corneal diameter

112

0.11 (0.27)

Average central keratometric power

112

0.03 (0.79)

Axial length

99

0.15 (0.14)

Intraocular pressure

112

0.07 (0.48)

Pupil diameter

99

0.05 (0.60)

Physiological characteristics of infant

Patient age at surgery

112

0.19 (0.041)

Gestational age at birth

100

−0.03 (0.78)

Birth weight

110

−0.04 (0.65)

Sociological characteristics of family

Primary caregiver age at surgery

109

−0.02 (0.87)



Table 5.3
Bivariate associations of categorical baseline characteristics and visual acuity at 4.5 years of age


































Baseline characteristic

# Patients

Visual acuity (logMAR)

Median (IQRa)

p-valueb

Characteristics of treated eye

Type of cataract

 Mild/possibly acquired

14

1.15 (0.30–1.60)

0.72

 Other

98

0.80 (0.30–1.70)

Orthotropic

 No

27

1.20 (0.70–1.92)

0.17

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Nov 21, 2017 | Posted by in OPHTHALMOLOGY | Comments Off on Baseline Predictors of Visual Outcome

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