Baseline characteristic
# Patients
Summary statisticsa
Characteristics of treated eye
Type of cataract (mild/possibly developmental)
114
14 (12 %)
Orthotropic (yes)
108
80 (74 %)
Corneal diameter (mm)
114
10.5 ± 0.7, 9.0–12.5
Average central keratometric power (D)
114
46.4 ± 2.7, 40.1–53.8
Axial length (mm)
101
18.0 ± 1.3, 15.6–21.9
Intraocular pressure (mmHg)
114
12.2 ± 4.9, 3.0–24.0
Pupil diameter (mm)
101
3.3 ± 1.0, 1.0–6.0
Aphakia treatment (IOL)
114
57 (50 %)
Physiological characteristics of infant
Patient age at surgery (months)
114
1.8 (1.2–3.2), 0.9–6.8
Patient age strata at surgery (49–210 days)
114
64 (56 %)
Gestational age at birth (weeks)
102
38.8 ± 1.3, 36–42
Birth weight (grams)
112
3457 ± 489, 2041–5087
Gender (female)
114
60 (53 %)
Race (white)
114
97 (85 %)
Hispanic (yes)
114
19 (17 %)
Sociological characteristics of family
Private insurance (yes)
114
70 (61 %)b
Primary caregiver age at surgery (years)
111
29.2 ± 5.7, 16.8–41.7
Highest education level of mother or father
High school graduate or less
111
24 (22 %)
Vocational/some college
40 (36 %)
College graduate
27 (24 %)
Graduate or professional school
20 (18 %)
Many of the characteristics of the treated eye were restricted by the inclusion and exclusion criteria for the IATS. Thus patients with a corneal diameter <9 mm or an intraocular pressure ≥25 mmHg were automatically excluded. Additionally, patients whose cataractous eye had persistent fetal vasculature (PFV) causing stretching of the ciliary processes or tractional detachment of the retina were not eligible. The presence of active uveitis or signs of previous episodes of uveitis, as well as retinal disease or optic nerve disease, that could limit the visual potential of the eye were also exclusion criteria. These are all likely poor prognostic factors, but will not be discussed in this chapter.
We used the 4.5 year recognition visual acuity (VA) data to explore the relationship between baseline variables and later visual outcome. Correlations were determined between each baseline characteristic as a single variable and logMAR VA. The results are shown in Tables 5.2 and 5.3, with statistical analyses from continuous baseline variables listed in Table 5.2 and analyses from categorical variables listed in Table 5.3. We found that only age at the time of surgery and type of health care insurance had any statistically significant relationship with logMAR VA in our sample. Nonetheless, we will initially discuss information obtained about the type of cataract.
Table 5.2
Bivariate associations of continuous baseline characteristics and visual acuity at 4.5 years of age
Baseline characteristic | # Patients | Spearman rank correlation coefficient for factor and visual acuity (p-value) |
---|---|---|
Characteristics of treated eye | ||
Corneal diameter | 112 | 0.11 (0.27) |
Average central keratometric power | 112 | 0.03 (0.79) |
Axial length | 99 | 0.15 (0.14) |
Intraocular pressure | 112 | 0.07 (0.48) |
Pupil diameter | 99 | 0.05 (0.60) |
Physiological characteristics of infant | ||
Patient age at surgery | 112 | 0.19 (0.041) |
Gestational age at birth | 100 | −0.03 (0.78) |
Birth weight | 110 | −0.04 (0.65) |
Sociological characteristics of family | ||
Primary caregiver age at surgery | 109 | −0.02 (0.87) |
Table 5.3
Bivariate associations of categorical baseline characteristics and visual acuity at 4.5 years of age
Baseline characteristic | # Patients | Visual acuity (logMAR) Median (IQRa) | p-valueb |
---|---|---|---|
Characteristics of treated eye | |||
Type of cataract | |||
Mild/possibly acquired | 14 | 1.15 (0.30–1.60) | 0.72 |
Other | 98 | 0.80 (0.30–1.70) | |
Orthotropic | |||
No | 27 | 1.20 (0.70–1.92) | 0.17
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