Acute Macular Neuroretinopathy
SALIENT FEATURES
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Acute macular neuroretinopathy (AMN) is a rare condition classically defined by a wedge-shaped or petaloid lesion directed toward the fovea (Figure 13.1).1,2
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This condition is typically found in Caucasian females in the third decade of life.2
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AMN has been shown to be associated with mainly nonspecific illnesses, use of oral contraceptives and vasoconstrictors, and potentially vasoactive events.2
OCT IMAGING
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OCT imaging is critical to make the diagnosis of AMN. NIR is also valuable and displays a tear drop or wedge-shaped hyporeflective lesion in the parafoveal region (Figure 13.2A).2
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Acutely, OCT most commonly displays hyperreflectivity of the outer nuclear layer (ONL) with radial extension into the Henle fiber (HFL) and outer plexiform layers (OPLs), suggesting photoreceptor cell body and axon disruption (Figure 13.2B).2,5FIGURE 13.1 Multicolor (A), near-infrared reflectance (NIR) (B) and en-face optical coherence tomography (OCT) (C) images of the characteristic petaloid pattern of acute macular neuroretinopathy (AMN). Note that the petaloid lesion identified with NIR and en-face OCT colocalizes with ellipsoid zone attenuation with the corresponding cross-sectional OCT B-scan.
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