The Tumor Survey



The Tumor Survey





By precedent, the present tumor survey does not include most of the orbital conditions associated with infectious agents, disruptions related to trauma, and Graves orbitopathy. In keeping with the format of prior editions, this chapter tabulates and updates the number, type, frequency, and age distribution of a series of consecutive, histologically verified tumors seen at Mayo Clinic between 1948 and 1997. A detailed analysis of individual tumor groups is undertaken in other chapters of this section.


Overview of Past Mayo Clinic Surveys, 1948 to 1987

In our 50-year collection of literature on orbital tumors (1948 to 1997), many clinicopathologic correlations, lists, and classifications pertaining to the frequency, prevalence, and incidence of these disorders have appeared. Some of these surveys from earlier years are now out of date because of the small size of the sample, the type of tumor selected for study, changes in nomenclature, and the like. Lists, however, can be considered “dynamic” and subject to change simply because of pathologic revisions and reclassifications.

We have reprinted the summary table from the third edition (see Table 3.1) and noted the variables that evolved in the tumor mix during the 40-year period 1948 to 1987. These variations from the expected norm may interest readers who want to compare and contrast their experiences with ours.

The survey tabulated in our third edition (1975 to 1987) added 612 consecutive cases to a cohort of 764 surveyed from 1948, bringing the total to 1,376 consecutive orbital tumors. The 612 cases seen over the 13-year period represent an average of 47 patients per year, 10 more per year than in the second series. A striking aspect of the second and third series is the consistency of percentages of primary, secondary, and metastatic lesions from 1948. The proportion of primary tumors declined from 45.0% to 41.7% with the addition of data from the third case series. In the secondary tumors, the change was a decline of only 0.9%, from 45.0% to 44.1%. The proportion of metastatic tumors increased from 7.0% to 8.1%. These minimal shifts in distribution underline the pathoanatomic stability of our tumor cohort.

A similar consistency prevailed among the major histologic tumor groups as cases were added to the series. Also, the five most common primary tumors remained the same from the first to the second series (i.e., hemangioma, non-Hodgkin lymphoma, inflammatory pseudotumor, meningioma, and optic nerve glioma).

In the third series, basal cell carcinoma replaced malignant melanoma as the fifth most frequent tumor among the secondary orbital tumors. The radiopaque therapy for ocular malignant melanoma probably is the contributing factor for this shift in incidence. On a further analysis of the third series, we found 1,036 neoplasms (1,036 out of 1,376), increasing the incidence to 75%. Of the 1,036 neoplasms, 659 were malignant and 377 were benign, a ratio of 1.7:1.

By 1987, several changes in terminology had occurred. Organizing hematoma, esthesioneuroblastoma, non-Hodgkin lymphoma, Langerhans histiocytosis, and angiomyoma replaced the terms hematic cyst, olfactory neuroblastoma, malignant lymphoma, histiocytosis X, and vascular leiomyoma, respectively. Acquired meningocele is a new addition, and we replaced the word generalized (second edition) with the more appropriate term multifocal.

About the time of the third edition, many physicians were interested in counting orbital tumors in pediatric patients. Four of the larger reviews of this type were by Eldrup-Jorgenson and Fledelius (1975), Iliff and Green (1978), Shields et al. (1986), and Bullock et al. (1989). Collectively they reported 809 cases. Our own tabulation totaled 212 cases, a 15% (212 out of 1,376) share of total patients.

Compilations of cases in the literature confirm the wide spectrum of tumor types in pediatric patients. Prominent in all these surveys is vascular hamartoma (capillary hemangioma), developmental cyst, rhabdomyosarcoma, optic nerve glioma, and plexiform neurofibroma. However, our series differs from other surveys because of the lower incidence of dermoid cyst. This lesion usually is said to be the most common orbital tumor of childhood. This

discrepancy probably is attributable to the inclusion of cysts in adnexal locations (eyebrow and eyelid) in many other series, whereas the cysts in our list were all retroseptal. The lower incidence of dermoid cyst in our series also may alter the ratio of benign to malignant lesions. In our pediatric cases, 70% (149 out of 212) were benign tumors and 30% (63 out of 212) were malignant. This is a considerably higher ratio of malignant tumors in children than that reported in the literature.








Table 3.1 Summary of 1,376 Consecutive Orbital Tumors, Mayo Clinic, 1948 to 1987




























































































































































































































































































































































































































































































































































































































Histologic Type Primary Secondary Metastatic Multifocal Totals
Carcinoid     2   2 (0.1%)
Carcinomas         311 (22.6%)
   Adenocarcinoma 5 15 74   94
   Adenoid cystic 22 26 1   49
   Basal cell   40     40
   Mucoepidermoid 2 3     5
   Sebaceous   4     4
   Squamous cell 2 102 6   110
   Transitional   6     6
   Undifferentiated   1 2   3
Cysts         166 (12.1%)
   Cephalocele   4     4
   Dermoid 30       30
   Conjunctival 2       2
   Mucocele   114     114
   Optic nerve sheath meningocele 2       2
   Organizing hematoma 10       10
   Respiratory tract   1     1
   Teratoma 3       3
Fibrous connective tissue         20 (1.5%)
   Fibromatosis 2 2     4
   Fibrosarcoma 4 6     10
   Fibrous histiocytoma 1 5     6
Granulation tissue   1     1 (0.1%)
Granuloma (unclassified) 3       3 (0.2%)
Hematopoietic         129 (9.4%)
   Amyloid 3       3
   Granulocytic sarcoma 1     1 2
   Leukemic infiltrate       2 2
   Lymphoid hyperplasia 2       2
   Multiple myeloma       6 6
   Non-Hodgkin lymphoma 61 6   45 112
   Plasmacytoma 2       2
Histiocytic         20 (1.5%)
   Langerhans cell 1 4   6 11
   Sarcoid and sarcoidosis 7     2 9
Indeterminate 1       1 (0.1%)
Inflammatory         98 (7.1%)
   Nonvasculitic 58       58
   Vasculitic, nongranulomatous 23       23
   Wegener granulomatosis 6 9   2 17
Malignant melanoma 4 35 4   43 (3.1%)
Meningioma 42 97     139 (10.1%)
Mesodermal and adipose         45 (3.3%)
   Lipoma 3       3
   Liposarcoma 3 1     4
   Rhabdomyosarcoma 17 21     38
Mixed         41 (3.0%)
   Benign 25 1     26
   Malignant 10 5     15
Nerve sheath         54 (3.9%)
   Malignant   1   2 3
   Neurilemmoma 15 1     16
   Neurofibroma (plexiform) 9     18 27
   Neurofibroma (solitary) 8       8
Neuroepithelial         73 (5.3%)
   Esthesioneuroblastoma   12     12
   Glioblastoma multiforme   1     1
   Medulloblastoma     1   1
   Neuroblastoma     19   19
   Optic nerve glioma 34       34
   Retinoblastoma   5 1   6
Osseous and cartilaginous         42 (3.0%)
   Adamantinoma   1     1
   Ameloblastoma   2     2
   Aneurysmal bone cyst   2     2
   Chondroma   1     1
   Chondrosarcoma 1   5   6
   Chordoma   1     1
   Fibrous dysplasia 5   1   6
   Osteogenic sarcoma 2 11     13
   Osteoma 3   7   10
Papilloma (epithelial)   3     3 (0.2%)
Vascular         131 (9.5%)
   Angiomyoma   1     1
   Capillary hemangioma 30       30
   Cavernous hemangioma 60       60
   Hamartoma   1     1
   Hemangiopericytoma 16   4 1 21
   Lymphangioma 18       18
Vascular malformations         54 (3.9%)
   Aneurysm 2   1   3
   Arteriovenous   5 42   47
   Varix   4     4
Total 574 (41.7%) 607 (44.1%) 111 (8.1%) 84 (6.1%) 1,376 (100.0%)

Also in the third edition, we referenced some 27 publications pertaining to the classification and frequency of orbital tumors. These were a heterogeneous collection of facts and figures. No two of these studies were identical in the coverage of the various parameters of an incidence survey. In an earlier year, 1979, after reviewing several surveys of such types, Jones and Jakobiec (1979) noted that there probably is no unbiased, parametrically complete tumor series, and efforts to blend and compare the data of one series with another still leave the goal of a true and perfect survey unrealized.


Mayo Clinic Survey, 1988 to 1997

Since the tabulation of orbital tumors in the 1948 to 1987 series (third edition), an additional 419 consecutive orbital tumors were surgically confirmed between 1988 and 1997 (see Table 3.2). The composite total is now 1,795 cases (see Table 3.3).








Table 3.2 Summary of 419 Consecutive Orbital Tumors, Mayo Clinic, 1988 to 1997
































































































































































































































































































































































































































































































































































































































































































































Histologic Type M/F P S MS U MF No. Totals
Carcinomas               100
   Adenocarcinoma 15/22 3 3 31     37  
   Adenoid cystic 7/8 7 8       15  
   Basal cell 7/5   12       12  
   Carcinoid 1/1 2         2  
   Carcinosarcoma 0/1   1       1  
   Mucoepidermoid 0/1 1         1  
   Sebaceous 2/4   6       6  
   Squamous cell 15/8   20 3     23  
   Undifferentiated 3/0   3       3  
Cysts and celes               31
   Dermoid 4/7 11         11  
   Hematocele 1/3 4         4  
   Inclusion 1/2   3       3  
   Microphthalmos with cyst 2/0 2         2  
   Mucocele 5/6   11       11  
Fibrous tissue               9
   Fibrosarcoma 2/3 1 4       5  
   Fibrous histiocytoma 1/0 1         1  
   Solitary fibrous tumor 0/3 3         3  
Hematopoietic               74
   Hodgkin disease 0/1 1         1  
   Lymphoid hyperplasia 3/5 8         8  
   Multiple myeloma 1/0         1 1  
   Non-Hodgkin lymphoma 35/29       22 42 64  
Histiocytic               7
   Eosinophilic granuloma 1/0       1   1  
   Sarcoidosis 0/6       3 3 6  
Inflammatory               34
   Pseudotumor 10/15 25         25  
Vasculitis (nongranulomatous) 1/3 4         4  
   Wegener granulomatosis 2/3       2 3 5  
Mesodermal and adipose               20
   Lipoma 0/1 1         1  
   Liposarcoma 2/0 2         2  
   Rhabdomyosarcoma 10/6 9 6 1     16  
   Xanthomatosis 0/1 1         1  
Mixed               1
   Malignant 1/0 1         1  
Nerve sheath               9
   Neurilemmoma 2/2 4         4  
   Neurofibroma (plexiform) 3/1 4         4  
   Neurofibroma (solitary) 0/1 1         1  
Neuroepithelial               5
   Esthesioneuroblastoma 3/0   3       3  
   Optic nerve glioma 1/0 1         1  
   Retinoblastoma 1/0   1       1  
Osseous and cartilaginous               17
   Aneurysmal bone cyst 1/0 1         1  
   Brown tumor 0/1 1         1  
   Chondrosarcoma 2/0 1 1       2  
   Fibrous dysplasia 4/2 6         6  
   Osteoma 2/0 1 1       2  
   Osteosarcoma 2/3 2 3       5  
Vascular               39
   Capillary hemangioma 0/4 4         4  
   Cavernous hemangioma 9/12 21         21  
   Fibroangioma 1/0   1       1  
   Hemangioma of bone 0/1 1         1  
   Hemangiopericytoma 1/2 3         3  
   Lymphangioma 5/4 9         9  
Vascular malformation               19
Carotid-cavernous fistula (high-flow) 1/1   2       2  
Carotid-cavernous fistula (low-flow) 0/12   12       12  
   Varix 1/4 5         5  
Miscellaneous               54
   Malignant melanoma 8/7   7 8     15  
   Meningioma 17/22 22 17       39  
Total 196/223 174 125 43 28 49   419
F, female; M, male; P, primary; S, secondary; MS, metastatic; U, unifocal; MF, multifocal.

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jun 21, 2016 | Posted by in OTOLARYNGOLOGY | Comments Off on The Tumor Survey

Full access? Get Clinical Tree

Get Clinical Tree app for offline access