Primary Acute Angle-Closure and Chronic Angle-Closure Glaucoma
Primary Acute Angle-Closure and Chronic Angle-Closure Glaucoma
Christopher Kai-Shun Leung
BACKGROUND
Definition
Angle closure is characterized by iris apposition to the trabecular meshwork. The mechanisms of this anatomic abnormality can be categorized at four structural levels1:
• The pupillary margin (e.g., pupillary block)
• The ciliary body (e.g., plateau iris and iridociliary cysts)
• The lens (e.g., phacomorphic glaucoma)
• Posterior to the lens (e.g., malignant glaucoma)
Primary angle closure generally refers to the condition of an increase in resistance to the flow of aqueous humor at the pupillary margin (i.e., relative pupillary block).
The clinical course can be classified into three conceptual stages2:
Primary angle-closure suspects— individuals with narrow angles, usually defined as an angle in which more than 270 degrees of the posterior trabecular meshwork cannot be seen
Primary angle closure—defined by the presence of narrow angles combined with peripheral anterior synechiae, elevated intraocular pressure, or a past acute angle-closure attack
Primary angle-closure glaucoma— primary angle closure combined with evidence of glaucomatous optic neuropathy
More than half of primary angle-closure glaucoma patients are asymptomatic for many years (chronic angle-closure glaucoma) until an acute angle-closure attack or severe loss of vision occurs. Acute angle closure denotes a specific form of primary angle closure characterized by an acute elevation of intraocular pressure (usually more than 40 mm Hg). Patients complain of having symptoms of ocular pain, nausea, or vomiting, and demonstrate signs of conjunctival injection, corneal epithelial edema, mid-dilated pupil, and shallow anterior chamber.
Pathophysiology
In primary angle closure, the increase in resistance at the pupillary margin raises the pressure gradient between the anterior chamber (anterior to the iris) and the posterior chamber (posterior to the iris) (Fig. 17-1). The iris has a characteristic forward-bowing configuration, leading to narrowing of the angle (primary angle-closure suspect). The adhesion of the peripheral iris to the trabecular meshwork may obstruct the angle and result in elevation of intraocular pressure and formation of peripheral anterior synechiae (primary angle closure). If the degree of relative pupillary block is extensive and the angle is already very narrow, complete obstruction of the angle occurs, and the rise in intraocular pressure would be precipitous, leading to an acute attack (primary acute angle closure). If the degree of relative pupillary block is small and the trabecular meshwork is blocked only in small portions, the intraocular pressure may increase gradually over the years, resulting in chronic progressive degeneration of the optic nerve without development of any symptom (chronic angle-closure glaucoma).
FIGURE 17-1. Pathophysiology of primary angle closure. A drawing of an apposition of the pupillary margin to the anterior surface of the lens (A), aqueous pressure developing behind the iris (B) (arrows) and pushing the iris forward, and iris bombé (C) (arrows) causing obstruction of the trabecular meshwork.
Epidemiology
Although angle-closure glaucoma represents approximately 25% of glaucoma worldwide, it accounts for nearly half of glaucoma blindness.3 It is more prevalent in China, India, and Southeast Asia than in Europe and Latin America. A shallow anterior chamber, short axial length, and small corneal diameter are biometric risk factors for primary angle closure. The incidence of acute angle closure has been estimated at approximately 4 to 16 per 100,000 per year in the population aged 30 years and older.4 In addition to the biometric risk factors for primary angle closure, age more than 60 years, female gender, a positive family history, and a thick and bulky lens impose additional risks for acute attack.
Clinical Examination
Gonioscopy
Gonioscopy is an indispensable technique to visualize the angle structures and detect angle closure. It is important to perform gonioscopy in a completely darkened room using the smallest square of light for a slit beam that sets off the pupil because slit-lamp illumination can stimulate pupillary light reflex and widen the angle (Fig. 17-2). A narrow angle is usually defined as an angle in which more than 270 degrees of the posterior trabecular meshwork cannot be seen. Indentation gonioscopy is useful for differentiating synechial closure from appositional closure. Synechial closure is recognized when there are considerable acquired adhesions between the iris and the corneoscleral junction at the angle. Peripheral anterior synechiae may extend circumferentially, resulting in synechial closure and progressive increase in intraocular pressure (Fig. 17-3). The extent of peripheral anterior synechiae correlates with the risk of developing glaucoma.
Ultrasound Biomicroscopy and Optical Coherence Tomography
Although assessment of the angle with gonioscopy is largely qualitative and subjective, objective and reproducible measurement of the anterior chamber angle can be obtained with cross-sectional imaging devices like the ultrasound biomicroscopy (UBM) and the optical coherence tomography (OCT) (Fig. 17-4). OCT has a number of advantages over UBM for anterior chamber angle imaging. It is a noncontact technique, has a higher image resolution, and is more precise in locating the position of interest for evaluation compared with UBM. UBM, however, has a unique role in visualizing the ciliary body. Commercially available time-domain and spectral-domain models have been developed for anterior chamber angle imaging5 (Table 17-1). With the development of high-resolution OCT imaging systems, angle structures including the scleral spur, Schwalbe’s line, Schlemm’s canal, and collector channels can be examined in greater detail (Fig. 17-5). High-speed imaging allows evaluation of the angle in 360 degrees. Visualization of the iris profiles and the angle configurations is enhanced with three-dimensional reconstruction (Fig. 17-6). The latest anterior segment swept-source OCT (CASIA II, Tomey, Nagoya, Japan) provides automatic segmentation of the anterior segment structures and quantification of the anterior chamber angle dimensions in 360 degrees (Fig. 17-7). This new feature would improve the detection of primary angle closure. Examination of the anterior chamber angle with OCT and UBM not only augments the diagnostic performance to detect angle closure, but also improves our understanding in the pathophysiology of primary angle closure.
TABLE 17-1. Comparison of Commercially Available Optical Coherence Tomography (OCT) Systems for Anterior Chamber Angle Imaging