Granulomatosis with Polyangiitis





History of Present Illness


A 54-year-old woman with history of asthma and appendiceal adenocarcinoma status post-appendectomy presented to the emergency department with 3 weeks of shortness of breath, sinus congestion, cough productive of green sputum, lower extremity edema, and general malaise. She had been treated with 2 weeks of oral amoxicillin–clavulanate without improvement. She was found to be hypoxemic with oxygen saturation of 89% on room air and multiple opacities on chest x-ray. She had an elevated white blood cell count of 33,680/μL (95% neutrophils). Computed tomography (CT) scan of the chest revealed diffuse alveolar hemorrhages, which were confirmed on bronchoscopy. She was admitted to the hospital and subsequently developed oliguric acute renal failure. A renal biopsy was performed, revealing crescentic glomerulonephritis. She was given 4 days of intravenous (IV) methylprednisolone 1 g/day and one dose of 880 mg IV cyclophosphamide. Routine blood culture grew out yeast, and ophthalmology was consulted to evaluate for possible fungal endophthalmitis.



Exam












































OD OS
Visual acuity 20/25 20/25
Intraocular pressure 17 18
Sclera/conjunctiva White and quiet White and quiet
Cornea Clear Clear
Anterior chamber Deep and quiet Deep and quiet
Iris Unremarkable Unremarkable
Lens Clear Clear
Anterior vitreous Clear Clear
Dilated fundus examination (DFE) See Fig. 61.1A See Fig. 61.1B



Fig. 61.1


(A) Color fundus photograph of the right eye showing clear media, healthy nerve, normal vasculature, and a few cotton wool spots. (B) Color fundus photograph of the left eye showing clear media, moderate optic nerve cupping, and rare dot blot hemorrhages in the inferior periphery.

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Apr 3, 2021 | Posted by in OPHTHALMOLOGY | Comments Off on Granulomatosis with Polyangiitis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access